The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine preparation for treating advanced breast cancer by virtue of combined chemotherapy and a preparation method of the traditional Chinese medicine preparation. The preparation is prepared from the following medicinal materials: rhizoma cyperi, fingered citron, radix pseudostellariae, deer-horn glue, placenta hominis, spatholobus suberctu, fritillary bulb, pinellia ternata, indigo naturalis and licorice root. The traditional Chinese medicine preparation has the advantages of simple prescription, exquisite drug usage and reasonable compatibility, has magical effects of soothing liver, strengthening spleen, promoting qi circulation, relieving depression, promoting blood circulation to remove stasis, clearing heat and eliminating stagnation, has an extremely targeted curative effect on combined chemotherapy of advanced breast cancer, can be used for remarkably reducing toxic or side effects generated by chemotherapy, has a remarkable curative effect for improving physical strength and immunity, and is an effective medicine for treating advanced breast cancer by virtue of combined chemotherapy.