The invention provides an X70QS seamless line pipe with HIC (Hydrogen Induced Cracking) resistance, comprising the following components in weight by percentage: 0.06%-0.14% of C, 0.20%-0.45% of Si, 1.00%-1.30% of Mn, P not more than 0.015%, S not more than 0.003%, 0.05%-0.30% of Cr, 0.05%-0.30% of Mo, 0.015%-0.060% of Al, 0.003%-0.010% of N, 0.030%-0.050% of Nb, 0.05%-0.09% of V, not more than 0.10% of Ni, not more than 0.20% of Cu and the balance of Fe and impurities, wherein Ni and Cu which have limited content are residual element in the steel, the carbon equivalent CEpcm is not more than 0.22%, and CEIIW is not more than 0.39%. The X70QS seamless line pipe has the advantages of high strength and excellent impact performance and can ensure the impact power to be greater than 150J at -40 DEG C, which is much higher than the impact power standard values of the API (American Petroleum Institute) and the ISO (International Standards Organization); by controlling the CE and the PCM (Pulse-Code Modulation), the X70QS seamless line pipe qualitatively ensures better welding performance; the X70QS seamless line pipe has the advantages of high ductility, low yield ratio and high elongation; and the X70QS seamless line pipe has favorable HIC resistance, thereby ensuring that when the yield strength is greater than 485 MPa, the crack-sensitive rate CSR is not greater than 2%, the crack-length rate is not greater than 10%, and the crack-thickness rate CTR is not greater than 3%.