The invention discloses a
system for carrying out snoRNA and
disease association prediction based on a multi-graph SAGE network, and relates to the technical field of biological information, the
system comprises the following components: a
data acquisition and preprocessing module, which obtains data containing snoRNA and
disease association information from MNDRv3.1, carries out
feature extraction on a snoRNA sequence, calculates snoRNA
pairwise similarity by using a Tanimoto coefficient, and sends the snoRNA
pairwise similarity to the MNDRv3.1; meanwhile, the
disease pairwise similarity is obtained by adopting a DAG-based
semantic similarity method; according to the method, the multi-graph
heterogeneous network is constructed by integrating the paired
similarity data of the snoRNA and the disease and the associated network of the snoRNA and the disease, the feature information of the snoRNA and the disease is comprehensively captured by using the GraphSAGE architecture with an attention mechanism, the complex relationship between the snoRNA and the disease is effectively captured, the prediction precision of snoRNA-
disease association is remarkably improved, and the prediction efficiency of the snoRNA-
disease association is improved. According to the method, higher AUC, AUPRC and F1 scores are obtained on a
test set, higher classification capability and prediction reliability are displayed, and a more accurate prediction result is provided for biomedical researchers.