The embodiment of the invention provides a double-node upset prevention latch and relates to the technical field of an integrated circuit. The latch comprises a storage node A, a storage node B, a storage node C, a storage node D, a storage node E and a storage node F. The latch also comprises a first cross coupling structure, a second cross coupling structure, a third cross coupling structure, afourth cross coupling structure, a fifth cross coupling structure, a sixth cross coupling structure, a seventh cross coupling structure, an eighth cross coupling structure and a ninth cross coupling structure. According to the latch, the technical problem that in the prior art, the double-node upset cannot be prevented by the latch in a small area circuit structure is solved. According to the latch provided by the invention, the technical effects that the single event upset prevention capability of the digital integrated circuit in a bad condition is improved, the double-node upset is prevented, the reliability is high and the area cost is low are achieved.