The invention relates to an interface protection device which is dustproof and convenient for fixing a connector for a main computer, the interface protection device includes a first housing, a firstrotating shaft, a rotating side plate, a securing top cover, a dustproof mechanism, a first slide, a first chute, a second chute, a fixing mechanism, a bundle mechanism, a first screen, a heat sink, asecond screen, a third filter screen and a fourth filter screen, wherein one side of the first housing is provided with a first rotating shaft, one side of the first rotating shaft far away from thefirst housing is provided with a rotating side plate, one side of the rotating side plate far away from the first housing in the vertical direction is provided with a fixed top cover, and the dust prevention mechanism is arranged on one side of the first housing far away from the first housing. The interface protection device for computer mainframe is dustproof and convenient for fixing the connector, and can dissipate heat to the internal connector through the wind generated by the work of the radiating fan at the bottom of the device. The first filter screen and the second filter screen aredense metal screens, so that dust can be avoided from entering, and the heat dissipation effect of the device to the connector is better.