The invention provides a differential relay protection communication device based on 5G communication, a system and a method. The device comprises an electrical information acquisition module, a 5G communication module and a trip logic processing module, wherein the electrical information acquisition module is used for acquiring operation information of electrical equipment in real time; the 5G communication module is used for receiving the operation information of the electrical equipment that is collected by the electrical information acquisition module and realizing the operation information intercommunication between different electrical equipment; and the trip logic processing module is used for receiving the operation information of the electrical equipment that is transmitted by the5G communication module, judging the operation state of the power grid, and making a normal operation or switch trip command. According to the communication device, the system and the method, no conventional propagation medium is required, the cost of the device is greatly reduced, and the transmission rate is greatly improved, thus realizing real multi-node cooperative transmission and fault judgment and improving the reliability and stability of communication.