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A method for extracting traditional Chinese medicine components by micro-thermal explosion technology of atmospheric pressure sulfur trioxide gas

A technology of sulfur trioxide and micro-heat explosion, which is applied in the direction of separation methods, chemical instruments and methods, and medical preparations containing active ingredients, etc., which can solve the problems of poor crushing of traditional Chinese medicine, denaturation of active ingredients of drugs, and high temperature in the crushing process, etc. problems, to achieve the effects of low equipment requirements, reduced residues, and increased productivity

Active Publication Date: 2021-07-16
安徽安生生物化工科技有限责任公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, in recent years, the processing technology of ultrafine pulverization of Chinese herbal medicines has been developed, but there are difficulties such as low processing output, difficulty in crushing sugary and oily Chinese medicines, high temperature in the crushing process, and high energy consumption of the whole machine.
In 2017, Ming Jian et al. applied for a patent "a method for preparing polyphenols from tartary buckwheat bran by steam explosion pretreatment"; in 2005, Yuan Yitao et al. applied steam explosion technology in the extraction of ephedrine; using steam explosion to rupture cells , forming porosity, which is conducive to the subsequent extraction of solvents; but it is usually carried out at a high temperature of 160-180 ° C, which is likely to cause denaturation of the active ingredients of the drug and requires special equipment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Paeonol: an active ingredient extracted from the dry root bark of the Ranunculaceae plant peony. Paeonol is white or yellowish shiny needle crystal, colorless needle crystal (ethanol). Melting point 49-51℃, special smell, slightly spicy taste, soluble in ethanol and methanol, soluble in ether, acetone, benzene, chloroform and carbon disulfide, slightly soluble in water, soluble in hot water, insoluble in cold water, can Volatile with water vapor.

[0027] Utilize the inventive method to extract the paeonol in the paeonol, comprising the following steps:

[0028] Slight thermal explosion treatment: add paeonol with a water content of 5% to the heating reaction tank, and pass in 0.5% (w / w) of sulfur trioxide gas diluted with air, and carry out a slight thermal explosion reaction at 60°C, and the reaction lasts for 1.5h ;

[0029] Slightly heat-exploded paeonol is crushed through a 60-mesh sieve, and water is added to the flask at a ratio of 1:20, and sodium hydroxide i...

Embodiment 2

[0032] Ligustrazine (tetramethylpyrazine): colorless needle crystal, melting point 80-82°C (microscopic determination), boiling point 190°C. Has a special odor, hygroscopicity, easy sublimation. Soluble in hot water, petroleum ether, soluble in chloroform, dilute hydrochloric acid, slightly soluble in ether, insoluble in cold water. During the extraction of ligustrazine, the peak of ligustrazine could not be detected after standing for 3 days without adding acetic acid. Considering that it is more appropriate to extract in an acidic environment, 5% acetic acid is added to the extraction solvent.

[0033] Utilize the method of the present invention to extract Ligustrazine, the method comprises the following steps:

[0034] Slight thermal explosion treatment: cut the decoction pieces of Chuanxiong with 10% water content into 1-2 cm, put them into the heating reaction tank, pass in air-diluted sulfur trioxide gas 0.8% (w / w), and carry out micro-explosion at 70°C. Thermal explosi...

Embodiment 3

[0038] Baicalin: a flavonoid compound extracted from Scutellaria baicalensis root, it is a light yellow powder at room temperature, with a bitter taste. Insoluble in methanol, ethanol, acetone, slightly soluble in chloroform and nitrobenzene, almost insoluble in water, soluble in hot acetic acid. It has antibacterial, diuretic, anti-inflammatory, cholesterol-lowering, anti-thrombotic, asthma-relieving, purging fire and detoxification, hemostatic, anti-fetal, anti-allergic and antispasmodic effects.

[0039] Utilize the inventive method to extract baicalin in Scutellaria baicalensis, comprise the following steps:

[0040] Scutellaria baicalensis with a water content of 8% was put into a heated reaction tank, and 1% (w / w) of sulfur trioxide gas diluted with air was introduced, and a slight thermal explosion reaction was carried out at 50°C, and the reaction lasted for 1.5 h;

[0041] Slightly heat the Scutellaria baicalensis powder, pass through a 60-mesh sieve, add 10 times th...

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Abstract

The invention discloses a method for extracting traditional Chinese medicine components by micro-thermal explosion technology of sulfur trioxide gas at atmospheric pressure, which comprises crushing Chinese medicinal materials, atmospheric pressure SO 3 Steps such as gas micro-thermal explosion pretreatment, traditional extraction and separation. The present invention will SO 3 As a pretreatment method for Chinese herbal medicines, micro-heat blasting straw pretreatment technology, combined with the extraction and separation process, improves the extraction yield and extraction efficiency of Chinese medicines, increasing the extraction yield of Chinese medicines by 10-40%. It is easy to operate, reduces energy consumption, and protects the environment. It has extremely high application value.

Description

technical field [0001] The invention belongs to the technical field of extracting traditional Chinese medicines, and in particular relates to a method for extracting traditional Chinese medicine components by the micro-thermal explosion technology of atmospheric pressure sulfur trioxide gas. Background technique [0002] Traditional Chinese medicine extraction methods include the following: (1) Dipping method: soak the treated medicinal materials with an appropriate solvent at room temperature or warm (60-80°C) to dissolve the ingredients; (2) Reflux Method: use ethanol and other volatile organic solvents to extract the ingredients of medicinal materials, the extract solution is heated, and after the solvent is distilled off, it is condensed and flowed back to the extractor to extract the medicinal materials, and this is repeated until the active ingredients are completely extracted; (3) Steam distillation: refers to the co-distillation of medicinal materials containing vola...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D11/02A61K36/00
CPCA61K36/00A61K2236/30B01D11/02B01D2011/007
Inventor 姚日生吴欢汪水玲李凤和边侠玲朱慧霞
Owner 安徽安生生物化工科技有限责任公司
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