29 results about "Hyperpigment" patented technology

The invention relates to a light loss repairing composition for improving skin resistance and application of the light loss repairing composition, and belongs to the technical field of cosmetics. The light loss repairing composition for improving the self resistance of the skin comprises the nannochloropsis oculata extract, the butterflybush flower extract and the bisabolol, all the components have a synergistic effect, ultraviolet light and blue light can be protected, and the light loss repairing composition has an anti-light aging effect and can be used for repairing the self resistance of the skin. And the mask has the effects of repairing skin barrier, relieving skin inflammation, improving redness, preventing hyperpigmentation, resisting aging, tightening skin, improving skin state and the like, and has the effect of improving self resistance of the skin.

Compositions comprising specific tetrapeptides, for use in methods for treating, preventing, minimizing, diminishing or reversing various signs of aging of the skin are provided. The compositions are useful in improving the firmness or elasticity of skin, smoothing of fine-lines or wrinkles, reducing skin pores and hyperpigmentation, and increasing skin thickness, radiance and / or softness.

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin synthesis in melanocytes and inhibiting melanin body migration. Therefore, the peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

To provide a method for treating a disease. [Solution] The present invention relates to compounds, compositions and methods for modulating skin pigmentation in a subject, and for treating or preventing UV-induced skin damage, erythema, skin aging, sunburn and hyperpigmentation. The compounds, compositions and methods of the present invention generally include compounds derived from Malassezia, including malassezin and indirubin, and / or their chemical analogues. Other uses of the compounds and compositions disclosed herein include, but are not limited to, improvement of hyperpigmentation caused by hyperpigmentation disorders, including melanocyte apoptosis, and modulation of aromatic hydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogeneration, melanosome transport, melanocyte activity and melanin concentration.

The present disclosure is related to a topical formulation comprising clascoterone in a mixture of aqueous and oily gel phases. The present disclosure further relates to a method of treating or preventing skin conditions such acne vulgaris, acne conglobata, acne fulminans, androgenetic alopecia, hidradenitis suppurativa (also known as acne inversa), hirsutism, cancer-therapy-induced rash, eczema, rosacea, atopic dermatitis, psoriasis, inverse psoriasis, seborrheic dermatitis, acanthosis nigricans, wound, and female pattern hair loss, comprising topically administering to a subject in need thereof an effective amount of the formulation.

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin body uptake in keratinocytes. The peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

Methods of treating a patient suffering from one or more of epidermal disorders of persistent inflammation—cell kinetics and differentiation disorders, epidermal disorders of persistent inflammation—altered reactivity disorders, disorders of the lips, oral, or vaginal mucosa, epidermal disorders of cohesion—vesicular and bullous disorders, cutaneous lymphomas, skin manifestations of rheumatologic diseases, hypomelanoses and hypermelanoses, or skin manifestations related to oncology treatments. The methods include topical administration of a pharmaceutical composition comprising a therapeutically effective amount of roflumilast.

L'OREAL The present invention relates to methods for obtaining a plant extract from flowering tops of Inula helenium, as well as plant extracts of Inula helenium, compositions comprising them, and their implementation to prevent and / or treat a pigmentary disorder, in particular (i) a pigmentary spot, in particular an actinic lentigo, (ii) a post-inflammatory hyperpigmentation, in particular linked to a scar or an unsightly disorder following an inflammatory skin manifestation, in particular a scar or an acne mark or (iii) a melasma.

Provided are compositions and methods for decreasing hyperpigmentation of a subject in need thereof. In some embodiments, the methods comprise administering a composition comprising a compound having a structure of Formulas (I) or (II), or a salt thereof.

The peptides of the present invention exhibit skin-whitening activity by inhibiting the absorption of melanosomes in keratinocytes. Therefore, the peptides of the present invention can be used as active ingredients in medicaments for treating or preventing hyperpigmentation caused by excessive melanosome deposition, or as active ingredients in cosmetics for skin whitening.

A dual-surfaced exfoliating and cleansing cloth is disclosed, comprising a first side formed of knotted nylon mesh with raised, interlocking knots configured to exfoliate the skin through rolling friction, and a second side formed of a soft, absorbent fabric such as a bamboo-cotton blend or microfiber textile for gentle cleansing. The cloth may be reusable, machine-washable, quick-drying, and resistant to microbial growth. It can be used to treat common skin conditions including acne, keratosis pilaris, and hyperpigmentation by combining effective exfoliation with skin-safe cleansing in a single article. A corresponding method of manufacturing the cloth is also disclosed, involving the formation of a uniform knotted nylon mesh and integration with a soft textile layer.

The present application relates to a kind of light damage repair composition of promoting skin's own resistance and its application, belong to cosmetic technical field.The light damage repair composition of promoting skin's own resistance provided in the present application includes Nannochloropsis oculata extract, buddleja extract, farnesol, each component synergistic effect, can realize the protection of ultraviolet light, blue light, has the effect of anti-photoaging, and can repair skin barrier, alleviate skin inflammation, improve redness, prevent excessive pigmentation, anti-aging tightness, improve skin state and the like function, with the effect of promoting skin's own resistance.

The disclosure is a peptide (Iaká (SEQ ID No1) with lightening action for periorbital hyperpigmentation, cosmetic or dermopharmaceutic composition containing this peptide and the use of this composition in the treatment of dark circles. Periorbital hyperpigmentation is a condition that does not add any risks to the patient's health state, however, it can cause aesthetic discomforts and appearance of tiredness. Dark circles can be formed due to anatomy or fat accumulation; due to a very thin skin thickness, allowing visualization of subcutaneous vessels; and, furthermore, due to melanin accumulation in the region. Due to this disclosure being a cosmetic composition, of topic non-invasive application, it can be applied daily without the requirement for an aesthetic specialist, besides not being as expensive as the currently known techniques for dark circles treatment. The peptide acts inhibiting melanogenesis.

This provides a new treatment for hyperpigmentation, a skin condition characterized by decreased pigmentation. [Solution] In one aspect, the present invention relates to a topical composition for the treatment of depigmentation skin diseases, comprising staurosporine or a pharmaceutically acceptable salt thereof as an active ingredient.

Disclosed herein are cosmetic compositions. More particularly, disclosed herein are cosmetic compositions comprising ubiquinone, and at least one skin care benefit agent selected from acetyl methionine, a salt thereof or combinations thereof for combating the harmful effects of atmospheric pollution relating to hyperpigmentation in human skin.

The present invention relates to the use of botulinum toxins for the treatment of hyperpigmentation conditions. The use includes intracutaneously injecting botulinum toxin into the skin of a patient with hyperpigmentation at a specific depth, volume and dose to specifically target the epidermal layer and the upper dermal layer. For example, an intradermal injection of botulinum toxin according to the invention may be used to treat chloasma.

Disclosed herein is a method for improving the appearance of blemish skin comprising applying to the skin a composition comprising a German chamomile essence component as an active ingredient and a physiologically acceptable carrier. In one embodiment, the method involves reducing comedo, sebum secretion, pore oversize, post-acne scars and expression lines, improving skin barrier function, and improving complexion by reducing redness, hyperpigmentation and post-acne hyperpigmentation.

The present invention relates to a method for producing cannabigerol and purifying it from a reaction mixture. The present invention also relates to the cosmetic use of cannabigerol for the inhibition of tyrosinase activity and / or the reduction of melanin production in the skin, in particular for reducing pigmentation of the skin, preferably for the improvement of the appearance of the skin in case of hyperpigmentation, lentigo or vitiligo. Furthermore, the present invention relates to cannabigerol for use in a therapeutic method for the inhibition of tyrosinase activity and / or the reduction of melanin production in the skin, preferably for use in a therapeutic method for the treatment and / or prevention of malign skin disorders, in particular skin cancer.

The present invention relates to the cosmetic, nutraceutical use of a strain of Lactobacillus crispatus, in particular that filed under number CNCM I-5579, and / or of a composition comprising it, to reduce pigmentation of the skin and / or mucous membranes and / or prevent its increase, in particular to preserve and / or improve the complexion of the skin and / or mucous membranes, preferably to preserve and / or improve the radiance and / or luminosity and / or homogeneity of the complexion of the skin and / or mucous membranes, and / or to prevent the appearance and / or reduce the presence of pigment spots on the skin and / or mucous membranes and / or detoxify the skin and / or mucous membranes.It also concerns the strain of Lactobacillus crispatus, or a dermatological composition comprising it, for its use, advantageously by topical route, for the treatment and / or prevention of pathologies of the skin and / or mucous membranes associated with an increase in pigmentation of the skin and / or mucous membranes, in particular to depigment and / or prevent hyperpigmentation of pathological skin and / or pathological mucous membranes.

The present invention relates to a method for producing cannabigerol and purifying it from a reaction mixture. The present invention also relates to the cosmetic use of cannabigerol for the inhibition of tyrosinase activity and / or the reduction of melanin production in the skin, in particular for reducing pigmentation of the skin, preferably for the improvement of the appearance of the skin in case of hyperpigmentation, lentigo or vitiligo. Furthermore, the present invention relates to cannabigerol for use in a therapeutic method for the inhibition of tyrosinase activity and / or the reduction of melanin production in the skin, preferably for use in a therapeutic method for the treatment and / or prevention of malign skin disorders, in particular skin cancer.

The present application relates to a whitening composition comprising a Nicotiana debneyi extract, and use thereof. The composition according to one embodiment regulates a melanin production pathway by reducing tyrosinase protein expression, and thus exhibits intracellular and extracellular melanin production inhibitory activity. Therefore, the present application provides a cosmetic composition for skin whitening, a health functional food composition for skin whitening, and a pharmaceutical composition for preventing or treating melanin hyperpigmentation diseases, all of which comprise the Nicotiana debneyi extract as an active ingredient.

The present application provides a class of resorcinol derivative compounds shown in formula A, which can be used for preparing drugs for inhibiting hyperpigmentation, and cosmetic, non-therapeutic uses for treating hyperpigmentation. The compounds of the present application have significant effects on inhibiting pigment deposition caused by ultraviolet and / or visible light radiation, skin anti-aging, etc. Wherein W is T is H, or R 1 to R 8 The definitions are as defined in the specification.

The present disclosure relates to polymer adhesive systems, articles, compositions or patches comprising a water-insoluble polymer matrix that contains a compound, whereupon application of an occluded patch to the mammalian skin, results in the release of the compound on to the skin and an into the skin. In one aspect, the rate of release of the compound can be fully or partially solubilized by water miscible and immiscible excipients, liposomes and lipid nanoparticles, and where the released compound is available in the treatment of immune related diseases such as atopic dermatitis, psoriasis, alopecia areata, acne and hyperpigmentation.

The present invention relates to a cosmetic composition for skin whitening and, specifically, to: a cosmetic composition for skin whitening, comprising, as an active ingredient, at least one compound selected from the group consisting of chemical formulas 1 to 12 according to the present invention or a salt thereof; a pharmaceutical composition for preventing or treating pigmentation or hyperpigmentation; and a health functional food for skin whitening or alleviating hyperpigmentation diseases. The compound according to the present invention can effectively inhibit the activity of tyrosinase, and at the same time, has the activity of inhibiting melanin production and melanin secretion, and thus can be used not only in the manufacture of functional cosmetics and health functional foods for skin whitening, but also as a therapeutic agent for diseases caused by melanin hyperpigmentation.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

Disclosed herein are cosmetic compositions. More particularly, disclosed herein are cosmetic compositions comprising at least one compound of General Formula (1), including but not limited to N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine (THEED), tetrahydroxypropyl ethylenediamine (THPE), and N,N,N',N'-tetrakis(2-hydroxypentyl)ethylenediamine, and at least one skin care benefit agent for combating the harmful effects of atmospheric pollution relating to hyperpigmentation in human skin.

The present invention relates to a 5-aminolevulinic acid derivative having improved storage stability and bioavailability, and a pharmaceutical composition comprising the same, the present invention exhibits a pharmacokinetic profile in which 5-aminolevulinic acid is more effectively exposed to blood in vivo, and reduces side effects after treatment, such as pain, erythema, swelling, edema, burning sensation, pruritus, spalling, hyperpigmentation and long-term stimulation and hypersensitivity. Further, the present invention relates to a 5-aminolevulinic acid derivative and a composition comprising the same, in which 5-aminolevulinic acid exhibits high efficiency while reducing the severity of side effects, and the 5-aminolevulinic acid derivative and the composition comprising the same are useful for photodynamic diagnosis and therapy.

This application relates to a skin-whitening composition comprising *Tobacco de Burgh* extract and its use. According to one aspect of the composition, melanin production pathways are regulated by reducing the expression of tyrosinase protein, thereby exhibiting both intracellular and extracellular melanin production inhibitory activity. Therefore, this application provides a cosmetic composition for skin whitening, a health food composition for skin whitening, and a pharmaceutical composition for the prevention or treatment of hypermelanosis, comprising *Tobacco de Burgh* extract as an active ingredient.

The present invention relates to processes for obtaining a plant extract of flowering tops of Inula helenium, and also to Inula helenium plant extracts, to compositions comprising same, and to the uses thereof for preventing and / or treating a chronic inflammatory skin disorder, in particular a pigmentary disorder, in particular (i) a pigmentary spot, in particular an actinic lentigo, (ii) a post-inflammatory hyperpigmentation, in particular associated with a scar or with an unaesthetic disorder consecutive to an inflammatory skin manifestation, in particular a scar or an acne mark, a scar or a rosacea mark or (iii) melasma.