Compounds of formula 1 are effective modulators of PI3
kinase: wherein R1 is H, hydroxy, amino, lower
alkyl, or trihalomethyl;R2 is amino, lower alkylamino, lower acylamino, arylamino, arylacyl-amino, heteroaryl-amino, heteroaryl-acyl amino, where
aryl and heteroaryl are substituted with 0-3 substituents selected from the group consisting of halo, trihalomethyl, hydroxy, lower
alkyl and lower alkoxy, or a
substituent of the form —(CH2)n—C(═X)—R8, where n is 014 3 inclusive and X is O or NR9, where R9 is H, lower
alkyl, or R1 and R2 together form —CH═N—X— where X is CH, NH, O, or S, and R8 is H, lower alkyl, lower alkoxy,
aryl, aralkyl, or —(CH2)mCR10R11R12, where m is 0-3 inclusive, and R10, R11, and R12 are each independently H, lower alkyl,
aryl, aralkyl, hydroxy, lower alkoxy, aryloxy, aralkoxy, amino, lower alkyl-amino, arylamino, aralkylamino, heteroaryl amino, or heteroaralkyl amino, where aryl and heteroaryl are substituted with 0-3 substituents selected from the group consisting of halo, hydroxy, and lower alkyl;R3 is H or lower alkyl; andR4, R5, R6, R7 are each independently H, halo, hydroxy, amino, nitro, lower alkyl, or lower alkoxy;and pharmaceutically acceptable salts thereof.