7 results about "Polyomavirus JC" patented technology

The invention relates to methods and reagents for analyzing samples for the presence of JC virus antibodies.

Provided herein are monoclonal antibodies and antigen-binding fragments thereof that bind to the John Cunningham virus. Also provided are pharmaceutical compositions comprising the monoclonal antibodies and antigen-binding fragments thereof, as well as methods of using such monoclonal antibodies and antigen-binding fragments thereof, including methods for the treatment and / or prevention of JCV infections and / or progressive multifocal leukoencephalopathy.

To provide polyomavirus epitopes useful for treating cancer or polyomavirus infection.SOLUTION: The present invention provides a peptide comprising a JC virus (JCV) epitope, the epitope being encoded by multiple specific amino acid sequences, the epitope being HLA class II restricted, one or more epitopes including one or more epitopes derived from a non-polyomavirus, and the one or more epitopes derived from a non-polyomavirus including one or more epitopes derived from an adenovirus, an Epstein-Barr virus, or a cytomegalovirus.SELECTED DRAWING: None

The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.

Provided herein are monoclonal antibodies and antigen-binding fragments thereof that bind to the John Cunningham virus. Also provided are pharmaceutical compositions comprising the monoclonal antibodies and antigen-binding fragments thereof, as well as methods of using such monoclonal antibodies and antigen-binding fragments thereof, including methods for the treatment and / or prevention of JCV infections and / or progressive multifocal leukoencephalopathy.

The application discloses a kind of graft injury multi-index combined noninvasive detection kit, by optimized multiplex real-time fluorescent quantitative polymerase chain reaction technology, realize the quantitative detection of six categories with closely related DNA virus after transplantation Complications, the present application relates to the field of in vitro detection technology of clinical sample.The graft injury multi-index combined noninvasive detection kit, the present application first realizes the synchronous detection of BK virus, JC virus, B19 virus, CMV virus, adenovirus and six kinds of closely related viruses of circovirus (TTV) with graft injury.Test data see example 7, from the detection results of 100 clinical kidney transplant patients, it can be seen that the kit of the present application can simultaneously accurately detect the load level of six viruses, to provide comprehensive infection risk assessment for clinicians.Compared with the prior art single virus detection method, the present application avoids the cumbersome process of multiple sampling and detection, significantly improves the clinical work efficiency.

To provide an anti-polyoma virus antibody and an antibody fragment for treatment of polyoma virus infection or reduction of probability thereof, and a method of using the antibody.SOLUTION: Provided is an antibody, where the antibody or an antigen-binding fragment thereof specifically binds to BK virus and / or JC virus. In one embodiment, the antibody or the antigen-binding fragment thereof binds to BKV serotype I, BKV serotype II, BKV serotype III or BKV serotype IV, or combination of serotypes I to IV. In another embodiment, the antibody or antigen-binding fragment thereof further binds to JC virus.SELECTED DRAWING: None