The invention provides a multi-satellite multi-station integrated scheduling method and system, and relates to the technical field of satellite scheduling. According to the embodiment of the invention, a diversified neighborhood structure is introduced according to an initial multi-satellite multi-station integrated scheduling scheme to obtain an optimal scheduling scheme, a local optimal solution is obtained quickly, and the solving quality is improved; whether the optimal scheduling scheme is caught in local optimum or not is judged, if yes, a disturbance mechanism is started to remove a part of observation tasks from the optimal scheduling scheme, the removed tasks are kept in an inactive table, and when one of the tasks is triggered, proposed three removal operators are called so as to improve the solving quality; the optimal scheduling scheme for removing part of observation tasks is traversed, the data transmission process is optimized, observation data downloading is arranged, unnecessary data downloading activities are canceled, unnecessary energy consumption is reduced, the satellite resource utilization rate is increased, meanwhile, time is saved, and more opportunities are provided for observation activities.