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8 results about "Zygosity" patented technology
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Zygosity (the noun, zygote, is from the Greek zygotos "yoked," from zygon "yoke") (/zaɪˈɡɒsɪti/) is the degree of similarity of the alleles for a trait in an organism. Most eukaryotes have two matching sets of chromosomes; that is, they are diploid. Diploid organisms have the same loci on each of their two sets of homologous chromosomes except that the sequences at these loci may differ between the two chromosomes in a matching pair and that a few chromosomes may be mismatched as part of a chromosomal sex-determination system. If both alleles of a diploid organism are the same, the organism is homozygous at that locus. If they are different, the organism is heterozygous at that locus. If one allele is missing, it is hemizygous, and, if both alleles are missing, it is nullizygous.
Assay methods for predicting alzheimer's disease using APOE and tau
The presently described and claimed technology relates immunoassay methods of assessing a subject's Alzheimer's Disease status and zygosity for the APOE ε4 allele.
Owner:BECKMAN COULTER INC
Generation and use of simulated genomic data
Embodiments of the invention utilize a graph-based approach for simulating genomic datasets from large scale populations. Genomic data may be represented as a directed acyclic graph (DAG) that incorporates individual sample data including variant type, position, and zygosity. A simulator may operate on the DAG to generate variant datasets based on probabilistic traversal of the DAG. This probabilistic traversal reflects genomic variant types associated with the subpopulation used to build the DAG, and as a result, the generated variant datasets maintain statistical fidelity to the original sample data.
Owner:SEVEN BRIDGES GENOMICS INC
Brassica cytoplasmic male sterility (CMS) fertility restorer nucleic acids, markers, methods, and zygosity assays
This disclosure concerns methods and compositions for identifying plants that have an Ogura CMS restorer of fertility phenotype. Some aspects concern a zygosity assay to identify, select, and / or construct Ogura CMS restorer of fertility plants and germplasm. Particular aspects concern a zygosity assay to maintain an Ogura fertility restoration system for hybrid canola production. This disclosure also concerns plants comprising an Ogura fertility restoration system for hybrid canola production generated by methods utilizing the zygosity assay described herein.
Owner:PIONEER HI BREED INTERNATIONAL INC
Methods and compositions for increasing harvestable yield via editing GA20 oxidase genes to generate short stature plants
ActiveUS12612642B2Climate change adaptationVector-based foreign material introductionBiotechnologyEnzyme Gene
The present disclosure provides compositions and methods for the editing or mutating of specific subtypes of GA20 oxidase genes and specific zygosity combinations of those edits or mutations. Modified plants, and plant parts and cells thereof, having mutations reducing the expression or activity of GA20 oxidase genes are further provided with improved characteristics, such as reduced plant height and increased lodging resistance, but without off-types. Methods are further provided for making modified plants, and plant parts and cells thereof, having one or more mutations in specific subtypes of GA20 oxidase genes.
Owner:MONSANTO TECHNOLOGY LLC
Resolving genome fractions using polymorphism counts
PendingUS20260038632A1Microbiological testing/measurementData visualisationMedicineRetrospective analysis
Methods of reliably estimating genomic fraction (e.g., fetal fraction) from polymorphisms such as small base variations or insertions-deletions are disclosed. Sequenced data from a multigenomic source is used to determine allele counts for one or more of the polymorphisms. For one or more of the polymorphisms, zygosity is assigned, and genomic fraction is determined from the zygosity and allele counts. Certain embodiments employ SNPs as the relevant polymorphism. The disclosed methods can be applied as part of an intentional, pre-designed re-sequencing study targeted against known polymorphisms or can be used in a retrospective analysis of variations found by coincidence in overlapping sequences generated from maternal plasma (or any other setting where a mixture of DNA from several people are present).
Owner:VERINATA HEALTH INC
New assays for phasing remote genomic loci with zygotic resolution via long read length sequencing mixed data analysis
The present invention describes a novel method for pre-clinical or clinical biomarker characterization, e.g. In the field of neuroscience, such as Huntington's Disease. The disclosed methods and kits can be used as companion diagnostic tools where identification of two or more paired loci is required to provide basic information for safe and efficient stratification of patients receiving specific therapy or drug treatment. More particularly, the methods allow for the accurate determination of the spatial relationship of single nucleotide polymorphisms (SNPs) to short tandem repeats (STRs) or another SNP from regions that are very distant from the genome in heterozygosity / homozygosity resolution.
Owner:F HOFFMANN LA ROCHE & CO AG
Zygosity-specific biomarkers of response to Anti-cancer therapy
PCT designated stageWO2026117733A1Microbiological testing/measurementAntibody ingredientsWild typeKEAP1
The present disclosure provides methods for selecting cancer patients for dual anti-CTLA4 and anti-PD-Ll / PD-1 immune checkpoint blockade (ICB) therapy based on biallelic inactivation (mutation plus copy number loss of wild-type allele, "MutLOH") in KEAP1 and STK11.
Owner:MEMORIAL SLOAN KETTERING CANCER CENT +2
Brassica cytoplasmic male sterility (CMS) fertility restorer nucleic acids, markers, methods, and zygosity assays
PendingUS20260076322A1Microbiological testing/measurementPlant genotype modificationBiotechnologyAssay
This disclosure concerns methods and compositions for identifying plants that have an Ogura CMS restorer of fertility phenotype. Some aspects concern a zygosity assay to identify, select, and / or construct Ogura CMS restorer of fertility plants and germplasm. Particular aspects concern a zygosity assay to maintain an Ogura fertility restoration system for hybrid canola production. This disclosure also concerns plants comprising an Ogura fertility restoration system for hybrid canola production generated by methods utilizing the zygosity assay described herein.
Owner:PIONEER HI BREED INTERNATIONAL INC