A vehicle side structure of a pickup truck includes a cabin; and a loading platform that is disposed adjacent to a rear side of the cabin in the vehicle forward-rearward direction, is configured to include a bottom plate, a pair of right and left side panels, and a tail gate, and is formed in a box shape that opens toward a vehicle upper side. Each of the right and left side panels includes a traveling wind inlet part that is disposed at an outer part of each of the right and left side panels in a vehicle width direction, opens toward a vehicle front side, and includes a first opening, a traveling wind blowing part that is disposed at an upper end part of each of the right and left side panels, opens toward the vehicle upper side, and includes a second opening, and an intermediate part.