The invention relates to a large parking lot intelligent management system technology suitable for large parking lot intelligent parking space distribution and picking management. A large parking lot intelligent management and parking space guidance system comprises handheld wireless equipment 1, an entrance gate 2, a system control center 3, an exit gate 4, an exit camera device 5, an entrance camera device 6, Zigbee control devices 7, wireless sensing control devices 8, parking spaces 9 and a parking space camera device 10. The system control center 3 is connected with the entrance gate 2, the exit gate 4, the exit camera device 5, the entrance camera device 6, the Zigbee control devices 7 in all regions and the parking space camera device 10 in a wired mode, data and instruction communications are conducted between the system control center 3 and the handheld wireless equipment 1 through the Zigbee control devices 7 in all regions and the wireless sensing control devices 8 in the regions, and therefore voice guide parking and picking are achieved, user-friendly guidance, charging, energy saving, security and protection functions of the parking spaces of a parking lot are achieved, using rate and management efficiency of the parking lot are improved and the workload of workers is reduced.