A kind of dimethoxycurcumin polymer micelle and its preparation method and medical application

A technology of dimethoxycurcumin and polymer glue, which is applied in the field of dimethoxycurcumin polymer micelles and its preparation, can solve the problem of low drug loading and encapsulation efficiency, far-flung requirements, and poor quality. Poor controllability and other problems, to achieve the effect of improving bioavailability, uniform distribution, and reducing leakage
CN105012234BInactive Publication Date: 2018-10-16YANTAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YANTAI UNIV
Publication Date
2018-10-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a dimethoxycurcumin polymer micelle and a preparation method, an injection or oral administration system for the polymer micelle, and medical application of the polymer micelle. The drug-loaded micelle employs an amphiphilic segmented copolymer as a carrier material and forms a typical core-shell structure in an aqueous solution through self-assembly; and the structure has uniform particle size distribution,solubility and thermodynamic stability of dimethoxycurcumin in an aqueous medium are substantially improved, leakage, degradation and metabolism of dimethoxycurcumin in the body are effectively reduced, and long circulation and tumor tissue passive targeting are realized, so drug effect and security are improved. According to specific needs of clinical indications, freeze-dried powder or preparations of other dosage forms can be prepared from the drug-loaded micelle provided by the invention for injection or oral administration of the micelle; and the micelle is used for resisting tumors, oxidation, inflammation, bacteria and aging, realizing immunoloregulation, reducing blood fat, resisting atherosclerosis and senile dementia, etc., and is especially applicable to combination with tumor radiotherapeutics and chemotherapeutics to exert sensitivity-enhancing, efficiency-improving and toxicity-attenuating effects.
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Description

technical field

[0001] The invention belongs to the technical field of nanomedicine, and relates to a dimethoxycurcumin polymer micelle, a preparation method and a medical application thereof. Background technique

[0002] Natural products have always been an important source of drug discovery and development [Newman JD, Cragg MG. Natural products as sources of new drug over the last 25 years. J Nat Prod 70 (2007)461.]. Turmeric is a natural yellow pigment derived from the rhizomes of ginger plants such as turmeric, turmeric, and zedoary. It is widely used as a condiment in Southeast Asia such as India. It has a long history of application in traditional medicine. The efficacy is mainly attributed to curcuminoids [Sharma RA, et al . Curcumin: the story sofa. Eur J Cancer 41 (2005): 1955.].

[0003]

[0004] In terms of chemical structure, curcuminoids are diferuloyl derivatives linked by β-diketones, in which the β-diketone structure has enol-keto tautomerism, and the m...

Claims

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