The invention discloses a system and a method of anti-spoofing notification based on cell-phone message contents. The method includes the steps: (A) acquiring short messages through a short message module, sending the short messages to a key information extraction module to extract key information from the short messages, and sending the key information to a CPU (central processing unit); (B) acquiring the short messages and the key information by the CPU, and sending the key information to a micro processor; (C) analyzing and processing the acquired key information by the micro processor, and generating notification information to send to the CPU; (D) inserting acquired notification information into the corresponding short messages by the CPU, displaying the short messages on a display screen. Contents of the received short message are analyzed by the anti-spoofing notification system; relevant key information of remittance, transfer and accounts of the contents are extracted; the key information is analyzed and processed by the micro processor; notification information such as 'Caution! Fraud!' is generated and inserted into the short messages by the CPU and then displayed on the display screen. By the aid of the system and the method of anti-spoofing notification, users can be visually and clearly notified and protected from frauds, when they receive the short messages of frauds and the like.