48 results about "Monoamine oxidase B inhibitors" patented technology

The present invention relates to combinatorial therapies for treating anxiety, depression or psychotic conditions using a lithium salt and a psychoactive drug selected from the group consisting of serotonin reuptake inhibitor, a 5HT2 receptor antagonist, an anticonvulsant, a norepinephrine reuptake inhibitor, an α-adrenoreceptor antagonist, an NK-3 antagonist, an NK-1 receptor antagonist, a PDE4 inhibitor, an Neuropeptide Y5 Receptor Antagonists, a D4 receptor antagonist, a 5HT1A receptor antagonist, a 5HT1D receptor antagonist, a CRF antagonist, a monoamine oxidase inhibitor, a sedative-hypnotic drug, and an atypical antipsychotic.

The invention provides novel compounds of formula I: that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and / or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).

Compositions and methods for treating, preventing, or reducing alcoholism, in particular methods for increasing patient compliance with therapies that require the intake of an ALDH inhibitor comprising the step of administering a monoamine oxidase B inhibitor.

Compositions and methods for treating, preventing, or reducing alcoholism, in particular methods for increasing patient compliance with therapies that require the intake of an ALDH inhibitor comprising the step of administering a monoamine oxidase B inhibitor.

The present invention relates to combinatorial therapies for treating anxiety, depression or psychotic conditions using a lithium salt and a psychoactive drug selected from the group consisting of serotonin reuptake inhibitor, a 5HT2 receptor antagonist, an anticonvulsant, a norepinephrine reuptake inhibitor, an α-adrenoreceptor antagonist, an NK-3 antagonist, an NK-1 receptor antagonist, a PDE4 inhibitor, an Neuropeptide Y5 Receptor Antagonists, a D4 receptor antagonist, a 5HT1A receptor antagonist, a 5HT1D receptor antagonist, a CRF antagonist, a monoamine oxidase inhibitor, a sedative-hypnotic drug, and an atypical antipsychotic.

The invention provides novel compounds of formula I:that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and / or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).

The invention provides novel compounds of formulae I and II: that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and / or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).

The invention relates to a medicinal composition taking a medicinal indianmulberry root oligosaccharide extract and a non-saccharide antidepressant medicament as active ingredients. The medicinal composition is characterized in that: the total content of inulin type oligosaccharide in the medicinal indianmulberry root oligosaccharide extract is 50 to 70 percent, and the content of inulin type penta-polyoligosaccharide is 5 to 15 percent; the non-saccharide antidepressant medicament comprises monoamine oxidase inhibitor type antidepressant medicaments such as moclobemide and the like, norepinephrine reuptake inhibitor type antidepressant medicaments such as imipramine, amitriptyline, maprotiline, doxepin, chlorimipramine or reboxetine and the like, selective 5-serotonin reuptake inhibitor type antidepressant medicaments such as fluoxetine, paroxetine, sertraline or citalopram and the like, or methylepinephrine / selective 5-serotonin dual reuptake inhibitor type non-saccharide antidepressant medicaments such as mirtazapine, duloxetine, venlafaxine or demethyl venlafaxine and the like. The invention also relates to the application of the medicinal composition taking the medicinal indianmulberry root oligosaccharide extract and the non-saccharide antidepressant medicament as the active ingredients in treating nervous and mental diseases such as depression, anxiety disorders, neuropathic pains and the like.

The present invention provides pharmaceutical compositions, which are useful for treatment of depression and the like, and which comprises a compound having an adenosine A2A receptor antagonistic activity such as (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or a pharmaceutically acceptable salt thereof and an antidepressant drug (for example, a tricyclic antidepressant, a tetracyclic antidepressant, a selective serotonin reuptake inhibitor, a selective noradrenalin reuptake inhibitor, a dopamine reuptake inhibitor, a serotonin-noradrenalin reuptake inhibitor, a monoamine oxidase inhibitor, a 5-HT2 antagonist or the like), and the like.

8-Hydroxy-quinoline derivatives and 8-ethers, 8-esters, 8-carbonates, 8-acyloxymethyl, 8- phosphates, (phosphoryloxy)methyl, and 8-carbamates derivatives thereof are described that exhibit iron chelation, neuroprotective, neurorestorative, apoptotic and / or selective MAO-AB inhibitory activities.

The invention provides novel compounds of formulae I and II:that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and / or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).

The invention provides novel compounds of formulae I and II: that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and / or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).

The invention relates to applications of liquidambar formosana hance fruit tannin monomer. The monomer comprises the components of gallic acid, ethyl gallate, p-digalloyl acid, and ethyl-p-digallate. The invention relates to the application of the monomer in preparing a monoamine oxidase inhibitor. The invention is characterized in that the invention relates to the applications of gallic acid, ethyl gallate, p-digalloyl acid, and ethyl-p-digallate in preparing medicines used for treating depression and Parkinson's disease.

The invention discloses beta-carboline derivatives with structural characteristics shown in a formula (I), and also discloses pharmaceutically acceptable salts of the beta-carboline derivatives, a preparation method of the beta-carboline derivatives and application of the beta-carboline derivatives as selective monoamine oxidase B inhibitors. The compounds of the invention are useful for the treatment of neuropsychiatric and degenerative diseases modulated by selective monoamine oxidase B inhibitors, including Parkinson's disease, Alzheimer's disease, obsessive-compulsive disorder, depression, schizophrenia, anorexia nervosa and migraine.

The invention discloses tricyclo-pyrazole [1,5-d] [1,4] benzo oxazepine-one derivatives of which the structure is shown in a general formula of a figure in the abstract. The invention simultaneously discloses the preparation method of the tricyclo-pyrazole [1,5-d] [1,4] benzo oxazepine-one derivatives. The invention further discloses the application of the tricyclo-pyrazole [1,5-d] [1,4] benzo oxazepine-one derivatives as a reversible and selective monoamine oxidase inhibitor drug, specifically, the tricyclo-pyrazole [1,5-d] [1,4] benzo oxazepine can be applied to drugs or drug compositions for treating and preventing diseases related to aging, alzheimer's disease and parkinson's disease.

8-Hydroxy-quinoline derivatives and 8-ethers, 8-esters, 8-carbonates, 8-acyloxymethyl, 8-phosphates, (phosphoryloxy)methyl, and 8-carbamates derivatives thereof are described that exhibit iron chelation, neuroprotective, neurorestorative, apoptotic and / or selective MAO-AB inhibitory activities.

According to the invention, a monoamine oxidase inhibitor with iron ion chelating activity is synthesized, and a pyridone derivative with iron ion chelating activity and a chromone mother nucleus with MAO-B inhibitory activity are innovatively and organically combined together; the compound has remarkable advantages on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease with complex pathogenesis.

The invention described herein provides a fast dispersing oral solid dosage form containing monoamine oxidase B inhibitor (MAO-B inhibitor) as the active ingredient, and method of treating disease therewith, such as Parkinson's disease. In one embodiment, the monoamine oxidase B inhibitor selegiline or its analogue can be the sole active ingredient in the composition administered. The dosage form composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and / or esophageal mucous membrane tissue, such that at least 5% of the active ingredient is absorbed within one minute of placement in the oral cavity, as determined by a buccal absorption test. Monoamine oxidase B inhibitor compounds administered in accordance with the invention decrease the amount of undesirable metabolites associated with first pass effect of selegiline, for example, such as amphetamine and methamphetamine. The invention provides a number of other advantages over conventional orally administered tablet forms, including administration of monoamine oxidase B inhibitor compounds to patients that have difficulty swallowing.

Compositions and methods for treating, preventing, or reducing alcoholism, in particular methods for increasing patient compliance with therapies that require the intake of an ALDH inhibitor comprising the step of administering a monoamine oxidase B inhibitor.

The present invention provides pharmaceutical compositions, which are useful for treatment of depression and the like, and which comprises a compound having an adenosine A2A receptor antagonistic activity such as (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or a pharmaceutically acceptable salt thereof and an antidepressant drug (for example, a tricyclic antidepressant, a tetracyclic antidepressant, a selective serotonin reuptake inhibitor, a selective noradrenalin reuptake inhibitor, a dopamine reuptake inhibitor, a serotonin-noradrenalin reuptake inhibitor, a monoamine oxidase inhibitor, a 5-HT2 antagonist or the like), and the like.

A first aspect of the invention relates to betahistine, or a pharmaceutically acceptable salt thereof, and a monoamine oxidase inhibitor, for use in the treatment or prevention of one or more symptoms of vertigo in a subject. A second aspect of the invention relates to a method of treating or preventing one or more symptoms of vertigo in a subject, said method comprising administering to the subject (i) betahistine, or a pharmaceutically acceptable salt thereof, and (ii) a monoamine oxidase inhibitor.

The invention discloses a purpose of a coumarin compound shown as a general formula (I) in preparation of a monoamine oxidase inhibitor, which belongs to the technical field of a medicine. Through in-vitro enzyme activity tests, the compound has good inhibition activity for monoamine oxidases A and B, and provides reference and novel thinking for developing the novel MAO inhibitor.

Selenium-containing benzobisfuran type compounds and preparation and applications thereof are disclosed. The structure formulas of the compounds are shown as a formula (X-a), a formula (X-b) and a formula (X-c), wherein R1 is a ketone group, an ester group or a cyano group, and R2 is C1-C6 alkyl, C1-C6 haloalkyl or aryl. A preparing route of the compounds is shown as follows. The compounds have good monoamine oxidase inhibitory activity and can be used for preparing monoamine oxidase inhibitors.

The invention discloses a method for synthesizing morabetamide, a novel monoamine oxidase inhibitor, which uses 5-chloro-2-pyridinecarboxylic acid as a starting material, first generates 5-chloro-2-pyridinecarboxylic acid chloride through acid chloride reaction, and then After amidation reaction, 5-chloro-N-(2-hydroxyethyl)-2-pyridinecarboxamide is generated, and finally condensed with morpholine to generate morapetamide. The compound morabetamine of the present invention adopts ethanolamine, 5-chloro-2-pyridine carboxylic acid and morpholine as main raw materials to prepare the novel monoamine oxidase inhibitor morabetamide, and the raw materials are easy to obtain. The production of morabetamide by the above method has the advantages of simple operation, good product purity and high yield, and is suitable for industrialized production.

The present invention provides systems, compositions and methods for treatment of dopaminergic disorders (e.g., Parkinson's disease) using the combination of a first compound that inhibits a voltage-gated calcium channel of the type Cav1.3 (e.g., a dihydropyridine such as isradipine), and a second compound that is monoamine oxidase inhibitor and / or is a nitric oxide synthase inhibitor (e.g., rasagiline or derivative thereof).

The invention discloses an application of 1,3-benzoxazolethiol-2-one compounds, which are shown as Formula (I), in preparing a monoamine oxidase inhibitor. Based upon in-vitro enzymatic activity experimental tests, it is indicated that the compounds have good inhibitory activity on both monoamine oxidase A and monoamine oxidase B; therefore, a reference and a new thought are provided and developedfor the development of the novel MAO inhibitor (monoamine oxidase inhibitor) (shown as the Description).

The invention relates to a pharmaceutical composition comprising Morinda officinalis oligosaccharide extract and a non-sugar antidepressant as active components. It is characterized in that the total content of inulin-type oligosaccharides in the extract of Morinda officinalis oligosaccharides is 50-70%, and the content of inulin-type pentameric oligosaccharides is 5-15%; non-sugar antidepressants include Monoamine oxidase inhibitor antidepressant drugs such as moclobemide, norepinephrine reuptake inhibitor antidepressant drugs such as imipramine, amitriptyline, maprotiline, doxepin, clomipa antidepressants such as fluoxetine, paroxetine, sertraline or citalopram, etc., or dual norepinephrine / selective serotonin Non-carbohydrate antidepressants of the reuptake inhibitor class, such as mirtazapine, duloxetine, venlafaxine, or desmethylvenlafaxine. The present invention also relates to the use of the pharmaceutical composition of Morinda officinalis oligosaccharide extract and a non-saccharide antidepressant drug as active ingredients in treating neuropsychiatric diseases such as depression, anxiety, and neurogenic pain.