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30 results about "Octanol water partition" patented technology

Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia

The present invention incorporates weakly basic substituents (pKa about 8 or greater) such as pyrrolidine, piperidine, piperazine and azapane moieties in halogenated 2-nitromidazoles as a major improvement over prior art for the non-invasive detection of cellular hypoxia in normal and malignant tissues. The invention features the use of [18F] positron emission tomography, [19F] magnetic resonance spectroscopy, and [19F] magnetic resonance imaging. Improvements over prior art compounds are six-fold. 1) Salts of weakly basic reagents are highly water-soluble which facilitates administration. 2) Unreacted reagents are rapidly cleared from systemic circulation thereby decreasing background noise. 3) Reagents with weakly basic substituents are concentrated in tissue ˜3 fold above plasma levels thereby increasing binding intensity and enhancing signal detection. 4) Conjugate bases of weakly basic reagents have intermediate octanol-water partition coefficients that facilitate their penetration into all tissues including brain. 5) Cellular adducts of reagents containing weakly basic substituents are more stable than reagents of prior art. 6) Reagents with weakly basic substituents are effective for the detection of transient hypoxia in solid tissue.
Owner:NATURAL PHARMACIA INT

Polymer adsorbent / cellulose acetate composite membrane material and preparation method and application thereof

The invention discloses a polymer adsorbent / cellulose acetate composite membrane material and a preparation method and application thereof. The preparation method of the composite membrane material comprises the following steps: dissolving a polymer adsorbent and a cellulose acetate polymer into a solvent to obtain a film casting solution; and forming a film from the film casting solution to obtain the composite membrane material. The composite membrane material can be used for enrichment and passive collection of hydrophobic organic pollutants and hydrophilic organic pollutants from water bodies; the logKow of the hydrophobic organic pollutants or the hydrophilic organic pollutants is 1.49-9.47, Kow is octanol-water partition coefficient, and the organic pollutants comprises organic phosphate flame retardants, phenols, estrogen, organophosphorus pesticides and triazine pesticides and other organic compounds. The polymer adsorbent in the composite membrane material is particularly important for the passive collection of trace pollutants (usually nanogram per liter level) in the water environment, can be used for enrichment of pollution with the concentration time reaching 10<3>-10<6>, and greatly reduces the detection limit of the pollutants.
Owner:RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI

A kind of polymer adsorbent/cellulose acetate composite membrane material and its preparation method and application

The invention discloses a polymer adsorbent / cellulose acetate composite membrane material and a preparation method and application thereof. The preparation method of the composite membrane material comprises the following steps: dissolving a polymer adsorbent and a cellulose acetate polymer into a solvent to obtain a film casting solution; and forming a film from the film casting solution to obtain the composite membrane material. The composite membrane material can be used for enrichment and passive collection of hydrophobic organic pollutants and hydrophilic organic pollutants from water bodies; the logKow of the hydrophobic organic pollutants or the hydrophilic organic pollutants is 1.49-9.47, Kow is octanol-water partition coefficient, and the organic pollutants comprises organic phosphate flame retardants, phenols, estrogen, organophosphorus pesticides and triazine pesticides and other organic compounds. The polymer adsorbent in the composite membrane material is particularly important for the passive collection of trace pollutants (usually nanogram per liter level) in the water environment, can be used for enrichment of pollution with the concentration time reaching 10<3>-10<6>, and greatly reduces the detection limit of the pollutants.
Owner:RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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