Feed for channel catfish adults comprises, by weight, 2-4 parts of Bacillus subtilis powder, 1-4 parts of ferment bacteria, 0.5-0.9 part of solid photosynthetic bacteria, 0.8-1.2 parts of bdellovibrio bacteriovorus, 0.2-0.6 part of vitamin additive, 10-16 parts of mineral additive, 0.2-0.4 part of chelating agent, 60-80 parts of water hyacinth, 50-80 parts of edible fungi residue, 100-110 parts of distillers' grains, 40-60 parts of fishbone meal, 70-80 parts of rice bran, 10-16 parts of brown sugar, 45-55 parts of kongpo monkshood root, 40-50 parts of Cochinchina Momordica seed, 1-15 parts of Chinese stellera root and the like. Comparisons show that compound microorganism feed with the feed can help channel catfish adults to grow fast, with higher EPA content and less fish diseases, less fishes die of illness, the beneficial microorganisms in water can be more, and final quality is higher.