8 results about "Pulmonary tb" patented technology

A diagnosis marker for pulmonary tuberculosis infection and a diagnosis kit thereof belong to the technical field of pulmonary tuberculosis diagnosis and treatment.The marker for detecting pulmonary tuberculosis provided by the present application is a LINC01148 gene, and the LINC01148 gene can be detected by primers to effectively diagnose whether a patient has pulmonary tuberculosis or not; the transcript sequence of the LINC01148 gene is SEQ ID NO.1, and the primer sequences of the LINC01148 gene are SEQ ID NO.2 and SEQ ID NO.3.Meanwhile, it is found that inhibiting the expression of the LINC01148 gene can effectively inhibit the activity of tubercle bacillus in macrophages, so the siRNA of the LINC01148 gene can be used for treating pulmonary tuberculosis.

The invention relates to the technical field of auxiliary diagnosis of tuberculosis patients, in particular to a sampling device convenient for tuberculosis patients to use, which comprises a sputum cup, a sliding groove is arranged at the top end of the sputum cup along the periphery of the sputum cup, a pressing component is in sliding fit in the sliding groove, and a plurality of springs are arranged in the sliding groove; the top of the pressing assembly is fixedly connected with a protection assembly for surrounding the mouth of a patient; the inner bottom of the pressing assembly is fixedly connected with an opening and closing assembly for controlling the protection assembly to communicate with the sputum cup; an air bag ring is arranged on the inner wall of the protection assembly, a plurality of inflation channels are formed in the pressing assembly, and the inflation channels all extend into the protection assembly and communicate with the air bag ring. The pressing assembly drives the opening and closing assembly to be opened, the protection assembly surrounds the mouth, the air bag ring is attached to the skin around the mouth of a patient, droplet diffusion is reduced, the infection risk is reduced, the sampling safety is improved, and diagnosis of the pulmonary tuberculosis patient is assisted.

The invention belongs to the technical field of tuberculosis detection, and provides a microRNA combination for bimodal differentiation of tuberculosis infection, a kit and a detection system. Nine specific microRNAs and one specific internal reference microRNA are taken as markers, the microRNAs in plasma are rapidly released by adopting a direct splitting method, the relative expression quantity of the markers is synchronously detected in combination with a tailing method reverse transcription technology, a four-group primer grouping amplification technology and a fluorescent PCR technology, a comprehensive risk value is calculated through a built-in algorithm, and latent tuberculosis infection, active infection and a negative state are synchronously distinguished. According to the invention, sputum samples are not needed, the detection is rapid and efficient, the detection sensitivity and specificity of active tuberculosis infection reach 92%, the detection sensitivity and specificity of latent tuberculosis infection reach 93%, the detection specificity reaches 90%, the operation is convenient, and the application range is wide.

The application discloses a kind of risk factors prediction model of occurrence of initial treatment bacterium positive pulmonary tuberculosis lung cavity, belong to medical data processing technical field, the clinical data of initial treatment bacterium positive pulmonary tuberculosis patient is collected in the application, using single factor analysis, Lasso regression analysis and multivariate Logistic regression analysis, male, diabetes, smoking, white blood cell count and platelet / hemoglobin ratio are screened as the independent risk factors of initial treatment bacterium positive pulmonary tuberculosis causing lung cavity, and based on this, nomogram prediction model is constructed.H-L goodness-of-fit test, receiver operating characteristic curve and decision curve analysis are verified, the model has higher prediction efficiency and clinical practical value.The application can help clinical advance to predict and intervene the cavity caused by high-risk population of pulmonary tuberculosis, provide new ideas for the diagnosis and treatment of bacterium positive pulmonary tuberculosis causing cavity.

The invention relates to a traditional Chinese medicine formula for treating phthisis with a herba euphorbiae humifusae herbal medicine, and belongs to the technical field of traditional Chinese medicines. The composition is prepared from 5 parts of dried cochinchina knotweed herb, 1 part of herba hedyotis diffusae and 1.5 parts of Yunnan pleione bulbocodioides, and is prepared into honeyed pills with pagoda flower honey or linden honey according to the ratio of 1: 3 after being crushed and mixed, and each pill is 5g. The dry product of the herba leonuri needs to be dried in the shade and ground until the particle size is less than or equal to 80 meshes, and the herba leonuri is subjected to ethanol reflux extraction and concentration to form extract. Clinical tests show that after a patient takes the medicine for 15 days, the sputum bacteria negative conversion rate reaches 78.3%, the lung cavity closure rate is increased to 85% or above, the treatment course can be shortened to 6 months by combining the medicine with anti-tuberculosis western medicine, and the drug resistance rate is remarkably reduced. The invention solves the problems of long curative effect period and insufficient drug resistance treatment of the traditional Chinese medicine, and provides an efficient and low-toxicity traditional Chinese medicine solution for pulmonary tuberculosis treatment.

The invention relates to the technical field of health-care products, and provides a lung-ventilating and cough-relieving liquid traditional Chinese medicine for treating cough and a preparation method thereof.The lung-ventilating and cough-relieving liquid traditional Chinese medicine is prepared from, by weight, 80-90 parts of traditional Chinese medicine extracting solution, 0.4-0.8 part of compound stabilizer and 40-50 parts of deionized water. The lung-ventilating and cough-relieving liquid traditional Chinese medicine provided by the invention has good stability, further has the effects of efficiently dispelling wind, ventilating lung, relieving cough and reducing sputum, and has a good curative effect on diseases such as cough and pulmonary tuberculosis.

The invention discloses a sealed sputum collecting device for a pulmonary tuberculosis patient, and belongs to the technical field of medical instruments. The flexible collecting bag is used for collecting sputum and arranged in the container, and a spacing cavity is formed between the flexible collecting bag and the inner wall of the container; a negative pressure source; a first passage connecting the negative pressure source to the interior space of the collection bag; a second passage connecting the negative pressure source to the space; and the adjusting mechanism is arranged on the second passage and is used for adjusting the negative pressure intensity in the interval space so as to control the expansion degree of the collecting bag and the negative pressure level in the collecting bag. The sputum collecting device can adapt to patients in different stages, the negative pressure strength is adaptively and flexibly adjusted according to the sputum viscosity of the patients, the sputum collecting comfort is improved, and the pollution risk is reduced.

The invention belongs to the technical field of biology, and particularly relates to a biomarker for early prediction of pulmonary tuberculosis, application of the biomarker and a detection kit. The biomarker and the kit constructed according to the biomarker can predict early-stage pulmonary tuberculosis, the accuracy, specificity and sensitivity of pulmonary tuberculosis prediction are high, accurate and efficient prediction can be conducted on pulmonary tuberculosis, and the biomarker and the prediction model for predicting pulmonary tuberculosis can be applied to the field of pulmonary tuberculosis prediction. By adopting the biomarker and the detection kit disclosed by the invention, safe, non-invasive and high-accuracy prediction on whether a patient suffers from pulmonary tuberculosis can be realized.