The invention relates to the technical field of high-voltage switch equipment, and discloses an interlocking device of a high-voltage switchgear mechanism, the interlocking device comprises a high-voltage switch cabinet main body, a handcart chamber, a protection door, a circuit breaker, a control button, partition insulation mechanisms and an auxiliary carrying mechanism; the handcart chamber is arranged at the center position of the right side of the high-voltage switch cabinet main body; the plurality of partition insulation mechanisms are respectively arranged at the corresponding positions of the contacts of the handcart chamber; and the auxiliary carrying mechanism is arranged at the top end of the inner cavity of the handcart chamber. The interlocking device of the high-voltage switch equipment mechanism can replace an existing integral insulating partition plate to integrally block electric shock, closing or opening of a fixed-point electric shock connector is achieved, safety is improved, meanwhile, workers can conveniently conduct high-voltage nuclear phase detection operation, operation is simpler and more convenient, and practicability is high. And moreover, workers are assisted in carrying and mounting the circuit breaker, hands of the workers are prevented from stretching into the high-voltage switch cabinet, mistaken touch of the workers is prevented, and the safety is improved.