The invention provides an orthopedic surgery drug permeation treatment device, relates to the technical field of lumbar vertebra treatment, and aims to solve the problems that when an existing orthopedic surgery drug permeation treatment device is used. Due to the fact that a base plate is complex in connecting structure and inconvenient to disassemble and clean, the drug permeation effect is affected, and meanwhile the device is troublesome in drug adding process and inconvenient to use, medicine cannot be rapidly added or replaced, the use efficiency is low, the massage effect is not ideal during medicine feeding, and use is inconvenient. The device comprises a bracket, the bracket is of a trapezoidal section structure, a mounting base is arranged at the bottom of the bracket, and a bottom plate is fixedly mounted at the bottom end of the mounting base. The base plate is clamped in the clamping groove in an embedded mode, meanwhile, the knob is rotated, and the clamping block is clamped with the limiting groove, so that the base plate is quickly and stably mounted at the top of the bracket, the connecting mode is simple, the base plate is convenient to disassemble and clean, and the medicine permeation effect of the device is improved.