The invention discloses a three-dimensional mammary gland ultrasound image partition method based on homoplasmon and partial energy. The method includes that the three-dimensional mammary gland ultrasound image to be processed is inputted, the image to be processed is carried out an edge detection. A detected edge curved surface is carried out fitting. The homoplasmon and an overall energy functional are defined, and a numerical calculation is the last step. The three-dimensional mammary gland ultrasound image partition method based on homoplasmon and partial energy has the advantages that firstly, difficult problem that in the traditional method, a three dimensional neighboring window is hard to choose is solved, so that, the neighboring window is capable of varying together with the changes of spatial position of a voxel.The homoplasmon, to some extent, can guarantee that the neighborhood cannot step over an organization, can effectively differentiate the pixels with similar appearance but belonging to different organizations, and the homoplasmon is helpful for improving the extraction accuracy of the tumor outline. Secondly, defects that for a level set model based on the global information, the unevenness of the gray level is hard to overcome and a level set model based on the partial regional information is fallen into the local extremum are solved, the extraction.