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EGCG and gamma-aminobutyric acid composition, and preparation method and applications thereof

A technology of aminobutyric acid and composition, which is applied in the directions of drug combination, pill delivery, cardiovascular system diseases, etc., can solve the problems of poor stability of EGCG, adverse effects on product preparation, storage, circulation, and restricted compliance.

Inactive Publication Date: 2015-08-12
FUZHOU QIANZHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the disadvantage is that, on the one hand, EGCG has poor stability and is easily affected by factors such as temperature, water, pH, etc., especially when stored in a liquid environment for 7 days, its hydrolysis / degradation rate reaches more than 17%, even in a solid state Although the stability will be relatively improved, it is more sensitive to temperature and will gradually degrade in a hot environment, seriously affecting product quality and the development of EGCG preparations / products, and bringing serious adverse effects on product preparation, storage, circulation, etc.; On the other hand, the taste of EGCG is very bitter, which limits its application in medicine and food. It is difficult for consumers or patients to accept its bitter taste when it is taken orally directly, which seriously restricts the compliance of its application; The mechanism of action of the cerebrovascular is relatively simple, and it lacks the function of protecting the cardiovascular and cerebrovascular in an all-round way or treating cardiovascular and cerebrovascular diseases.

Method used

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  • EGCG and gamma-aminobutyric acid composition, and preparation method and applications thereof
  • EGCG and gamma-aminobutyric acid composition, and preparation method and applications thereof
  • EGCG and gamma-aminobutyric acid composition, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] The compound tablet of embodiment 1, EGCG and gamma-aminobutyric acid and preparation thereof

[0143] The prescription quantity is calculated by weight percentage and contains:

[0144] EGCG 5%~25%, preferably 15%,

[0145] γ-aminobutyric acid 7%~35%, preferably 25%,

[0146] Mannitol 20%~45%, preferably 37%,

[0147] Calcium hydrogen phosphate 8% to 25%, preferably 15%,

[0148] Sodium carboxymethyl starch 1%~10%, preferably 5%,

[0149] 2.5% hydroxypropyl cellulose aqueous solution Appropriate amount, preferably 2% based on hydroxypropyl cellulose,

[0150] Magnesium stearate 0.5% to 2%, preferably 1%;

[0151] Its preparation method includes: passing EGCG, γ-aminobutyric acid, mannitol, calcium hydrogen phosphate, and sodium carboxymethyl starch respectively through 80 mesh sieves, preferably 100 mesh, and weighing EGCG and mannitol Mix evenly to get A mixed powder, and mix γ-aminobutyric acid and calcium hydrogen phos...

Embodiment 2

[0156] Compound granule of embodiment 2, EGCG and gamma-aminobutyric acid and its preparation

[0157] The prescription quantity is calculated by weight percentage and contains:

[0158] EGCG 1%~6%, preferably 3%,

[0159] γ-aminobutyric acid 1%~10%, preferably 5%,

[0160] Granule auxiliary material 85%~98%, preferably fructose 92%;

[0161] Wherein the granule excipients include one or more of the following ingredients: fructose, xylitol, fructooligosaccharides, xylooligosaccharides, polydextrose, mannitol, sucrose, invert sugar (i.e. an equal mixture of glucose and fructose) ), glucose, resistant dextrin, sorbitol, maltose, isomalt, mannose, solid polyethylene glycols (such as polyethylene glycol-4000, polyethylene glycol-12000, polyethylene glycol Alcohol-6000, polyethylene glycol-2000, etc.), dextrin, cyclodextrin, maltodextrin, hydroxypropyl-β-cyclodextrin, microcrystalline cellulose, carboxymethyl cellulose, hydroxypropyl methylcellulose Vegetarian...

Embodiment 3

[0167] The compound capsule of embodiment 3, EGCG and gamma-aminobutyric acid and preparation thereof

[0168] The prescription quantity is calculated by weight percentage and contains:

[0169] EGCG 10%~30%, preferably 15%,

[0170] γ-aminobutyric acid 15%~35%, preferably 30%,

[0171] Mannitol 15%~40%, preferably 36%,

[0172] Pregelatinized starch 8%~25%, preferably 12%,

[0173] Sodium carboxymethyl starch 1%~10%, preferably 5%,

[0174] The ethanol solution of polyvinylpyrrolidone is an appropriate amount, preferably 1% with polyvinylpyrrolidone,

[0175] Magnesium stearate 0.5% to 2%, preferably 1%;

[0176] Its preparation method comprises: passing EGCG, γ-aminobutyric acid, mannitol, pregelatinized starch and sodium carboxymethyl starch through 80 mesh sieve respectively, preferably passing through 100 mesh sieve, after weighing according to the prescription amount, firstly mix EGCG and Mix γ-aminobutyric acid evenly to obtain mixed powder A, which is ready for u...

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Abstract

The invention provides a health product composition or a pharmaceutical composition containing EGCG and gamma-aminobutyric acid; a drug dosage form includes any pharmaceutically acceptable drug dosage form, and EGCG and gamma-aminobutyric acid are combined according to the weight ratio of (0.2-3):1; furthermore, the invention provides a preparation method of the composition, an application of the composition in preparation of drugs for prevention and treatment of cerebral ischemia, cerebral arteriosclerosis, cerebral embolism and cerebral apoplexy sequela, and an application of the composition in preparation of drugs for prevention and treatment of cerebral nerve degenerative change or cerebral dysfunction disease.

Description

technical field [0001] The present invention relates to a health product composition, its preparation method and application, specifically the composition of EGCG and γ-aminobutyric acid, its preparation method and application. The health product composition of the present invention includes but not limited to medicine, medical food, health food or functional food, common food and so on. Background technique [0002] EGCG, that is, epigallocatechin gallate, the structural formula is as follows, [0003] , [0004] EGCG is a natural compound extracted and separated from green tea. It is the most efficient active monomer component in tea polyphenols. It has good safety and a wide range of physiological activities. Studies have shown that EGCG has anti-tumor and anti-virus properties. , antibacterial, immune regulation, anti-free radical damage, anti-oxidation, anti-oxidative stress, anti-thrombosis, anti-arteriosclerosis, protection of the nervous system, anti-angiogenesis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K9/14A61K9/20A61K9/48A61K47/18A61P9/10A61P25/00A61P25/28A61K31/197
Inventor 张耿元王保红唐湘成俞世宏
Owner FUZHOU QIANZHENG PHARMA
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