The invention discloses a positioning, opening and clamping device for minimally invasive total hip arthroplasty. The device comprises a bed body, wherein a head supporting pad, a hand positioning device, a body positioning device, a bone clamping device and a to-be-operated leg positioning traction device are arranged on the bed body. According to the device disclosed by the invention, the head,hands, body and legs of a patient can be respectively positioned by virtue of each device, so that the patient lies on the side on the hospital bed and keeps a comfortable posture, influences on operative procedures are avoided, the operated leg can be moved in a multi-directional manner, an operation panel can be connected to control the movement of the leg, and a doctor is easy to operate. Moreover, the total hip is easily taken out, the operation efficiency is improved, the operative complications are decreased, and wide popularization is facilitated.