The invention discloses a nontoxic, environment-friendly and high-efficiency pesticide, which is prepared from the following raw materials in parts by weight: 2 to 6 parts of calcium hydroxide, 1 to 3 parts of matrine, 5 to 9 parts of fructus xanthii, 3 to 7 parts of sodium silicate, 2 to 5 parts of ethyl glycolate, 1.5 to 4 parts of biological prallethrin, 2 to 4 parts of permethrin, 12 to 16 parts of celastrus angulatus, 6 to 9 parts of indolebutyric acid, 12 to 18 parts of stabilizer, 15 to 18 parts of tea saponin, 3 to 6 parts of tetramethrin, 7 to 10 parts of organic solvent, 14 to 17 parts of pesticide additive and a proper amount of water. The nontoxic, environment-friendly and high-efficiency pesticide has characteristics of being safe to use, nontoxic, environment-friendly, trace-amount and high-efficiency and that the raw materials are easily obtained, and the like.