The invention provides a spatial multi-
omics integration method and device, equipment and a storage medium. Relates to the technical field of spatial multi-
omics. The method comprises the steps of obtaining a double-
omics data set, and constructing an adjacent graph containing a space graph and a feature
graph based on the double-
omics data set; by means of an in-omics integration module, graph
convolution is performed on the space graph and the feature graph, space and feature potential representations are spliced and input into a multi-layer
perceptron, and in-omics fusion representation is obtained; through an inter-omics integration module, performing weighted summation on the intra-omics fusion representation by using a multi-head attention mechanism to obtain a multi-omics potential representation; a space omics integration model is trained by means of a double learning strategy, multi-omics potential representation and original normalized
space mapping are guaranteed through private learning in omics, specific
feature coding is enhanced by introducing self-supervised contrast learning, alignment of different omics representations is restrained through
shared learning among omics, and space multi-omics integration is achieved. According to the method, more complex histological structure characteristics can be captured, and the analysis capability of a complex space structure is remarkably improved.