The invention belongs to the technical field of electric power system analysis, and discloses a power distribution network topology serial number generating method based on searching in power distribution network load flow calculation. According to the method, equivalent load nodes, T-shaped nodes and power source nodes in a distribution network simplified model are expressed through nodes in a topological graph; a section switch, an interconnection switch and a circuit breaker are expressed through branch circuits in the topological graph; the nodes and the branch circuits respectively correspond to a real serial number, and the real serial numbers cannot repeat any definition. The searching method is used for generating virtual serial numbers, after the nodes/branch circuits are newly added in the distribution network, the serial numbers only need to be distributed for the newly-added nodes/branch circuits, there is no need for original serial numbers to be changed, the virtual serial numbers are generated automatically by searching, the virtual serial numbers can achieve the load flow calculation function, the phenomenon that a large number of data in a power distribution automation database are updated under the condition that equipment is newly added on the distribution network and the distribution network is reconstructed is avoided, and therefore the method is of great positive significance to promoting the intelligent level of load flow calculation of the power distribution network.