A medicate diaper with sterilization and ventilation effect comprises elastic waist band, magic buckle, crotch area, elastic leg band, surface coating layer, absorbent core lay, leak-proof retaining wall, base cloth and front waist paste. The diaper can absorb urine quickly and effectively, the surface is soft, comfortable, dry and permeable, and can provide dry and comfortable environment for infants. The surface coating layer is made of hydrophilic non-woven material and made of forsythia suspensa, Chinese herbal medicine liquid of mountain sesame, Chinese nutgall, small flying yam grass, coptis root and wild chrysanthemum flower is mixed according to proportion, which has no irritation and allergic reaction to baby's tender skin, good permeability, instant water absorption, sterilization, heat clearing and dehumidification, reduces the occurrence of diaper rash and eczema of baby, and protects baby's health.