The invention relates to a famoxadone-containing sterilizing composition. The active ingredients of the sterilizing composition is one of famoxadone (A) and triazole-type compounds (B), wherein the triazole-type compounds are selected from tebuconazole, hexaconazole, difenoconazole, epoxiconazole, flusilazole, myclobutanil, penconazole, fluquinconazole, diniconazole, triazolone, propiconazole, triadimenol, flutriafol, bitertanol, cyproconazole and the like; and the mass ratio of the A to the B is 30:1 to 1:30, and the active components accounts for 10 to 70 percent of the mass of the composition. The composition can be prepared into various formulations such as emulsifiable solution, a suspending agent, aqueous emulsion, wettable powder, water dispersing particle, microemulsion and the like. The sterilizing composition of the invention is applied in fields of farmlands, orchards and like and used for preventing and controlling various plant diseases, particularly powdery mildew and rust diseases, on crop such as corn, vegetables, fruit trees and the like.