The invention discloses an RFID-based terminal asset information security management method and system, and the method comprises the steps: obtaining parameters related to an RFID sensor, a reader-writer, a positioning base station and a communication gateway, so as to build the connection relation of all hardware; uploading the parameter information and the connection relationship to a backgroundasset information security management platform for unified storage; comparing and analyzing the stored data information with basic asset data in a database and data collected in real time to obtain change information of the asset position at the current moment; and completing terminal asset security management by utilizing rules and strategies of related systems of the information security management system. According to the invention, asset positioning, tracking, automatic inventory and the like are realized, so that assets can be used in a safe and controllable range; and on the other hand,the use area, the use range, the purchase, the circulation, the inventory and the like of the assets are effectively and safely managed, the dynamic condition of each asset is known at any time, andterminal asset safety management is realized.