Provided in the present invention is a fractional-order difference analog-to-
digital converter for collecting a neural spike potential. Firstly, a fractional-order difference operator is designed to calculate arbitrary fractional-order
delta encoding, such that the sparsity of a neural spike potential can be more effectively utilized, thereby significantly improving the
compression ratio of the neural spike potential; moreover, the fractional-order difference analog-to-
digital converter has higher flexibility by means of tunable differential orders, and can adapt to a wider range of neural spike potential collection scenarios. Secondly, a fractional-order buffer module is designed, such that an arbitrary fractional-order
delta encoding value can be generated in a simple and efficient manner. Finally, a serialized
bitstream generator is designed, such that serialized packaging can be performed on fractional-order
delta data collected by a plurality of parallel channels, which not only exhibits high
scalability and is applicable to multi-channel collection, but also enables reliable
interfacing with a subsequent synchronous
clock wireless transmission system, thus avoiding overheads and latency of synchronous-asynchronous interface coordination, and further improving the efficiency of neural spike potential collection.