The invention relates to the technical field of vehicle chassis, and discloses a vehicle roll driving mechanism and a design method thereof. The vehicle roll driving mechanism includes a vehicle body,a balance rod, a crank, a connecting rod, a rocker, a positioning rod, swing arms, pull rods, wheels and shock absorbers, the crank, the connecting rod, the rocker and the positioning rod are sequentially and rotationally connected to form a crank rocker mechanism in the same relative motion plane, the crank and the connecting rod are overlapped and collinear to form a rocker limit position I, the crank and the connecting rod are stretched and collinear to form a rocker limit position II, and two limit positions of the rocker correspond to left and right limit roll of a vehicle. The inventionprovides the design method of the length, the roll function and the roll direction of each rod of the vehicle roll driving mechanism. Meanwhile, the invention provides two active roll three-wheeled vehicles applying the vehicle roll driving mechanism, so that the vehicle body actively tilts by a certain angle to resist centrifugal force or roll force when the vehicle passes through a corner or passes through an inclined road surface, and the stable driving posture of the vehicle is kept.