The invention discloses a basin water quality real-time simulation method based on general calculation. The basin water quality real-time simulation method comprises the following steps: dividing basin grids under a general calculation framework; and performing parallelization design of a basin water quality model, wherein the step S1 comprises sequentially executing contents listed in 1.1, 1.2 and 1.3; 1.1, dividing basin grids in a grid mode; 1.2, defining a simulation grid; 1.3, constructing a grid neighborhood topology, and the step S2 comprises sequentially executing contents listed in 2.1, 2.2, 2.3, 2.4 and 2.5; 2.1, universally calculating basic requirements on a water quality model; 2.2, simulating attributes of the grids; 2.3, designing a hydrodynamic parallel algorithm of the simulation grid; 2.4, designing a water quality simulation parallel algorithm of a simulation grid. According to the simulation method, the water quality can be simulated in real time, and the simulationprecision also reaches an ideal effect.