The invention provides an LED display screen control system (30). The LED display screen control system comprises a front-end controller (31), an LED lamp panel module (35), and a scanning card (33) connected between the front-end controller (31) and the LED lamp panel module (35), wherein the scanning card (33) comprises a first chip (333), and the LED lamp panel module (35) comprises a second chip (351); the first chip (333) is used for receiving and unpacking a data packet coming from the front-end controller (31), processing the image data obtained by unpacking the data packet, and repacking the processed image data, so that the processed image data packet is obtained, output and transmitted to the second chip (351) of the LED lamp panel module (35) in the differential signal manner; the second chip (351) is used for receiving and unpacking the processed image data packet coming from the first chip (333), and generating a control signal and a display data set according to the image data obtained by unpacking the processed image data packet, wherein the control signal and the display data set are transmitted to an LED drive circuit (355) on the LED lamp panel module (35) for carrying out display drive. Therefore, with the LED display screen control system, the problem that the signal transmission stability between the LED lamp panel module and the scanning card is poor is solved.