38results about How to "Preventing translation" patented technology

Suture Locks, as well as related systems and methods, are provided for fixing strands of one or more sutures relative to tissue. The suture locks, systems and methods are simple and reliable in use, facilitate complete perforation closure and adjustment of the suture strands, and are adaptable to a variety of suture fixation and perforation closure situations. The suture lock includes a locking pin and a retaining sleeve. The locking pin has a main body and a grip. The retaining sleeve has a tubular body with an internal wall defining an internal passageway sized to receive the locking pin therein. The suture lock is operable between a locked configuration and unlocked configuration. In the locked configuration, the suture strands are compressed between the grip and the internal wall of the tubular body.

Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and / or prevention of age-related macular degeneration and / or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject.

The present invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-1 and methods for using this composition to treat inflammatory disease of ocular and adnexal tissues by topical administration. The present invention also discloses devices for delivering this composition to target tissues.

The invention relates to a system for stable maintenance of a plasmid, to host cells for use in this system and to methods of using the system to obtain a plasmid useful in medical applications. In particular, the invention provides transformed host cell containing: i) a chromosomal gene which inhibits cell growth; and ii) a plasmid encoding an antisense sequence, wherein the antisense sequence encoded by the plasmid inhibits the action of the chromosomal gene, thereby permitting cell growth and a method for stable maintenance of a plasmid in a host cell in vivo.

A bar armor system is provided for reducing damage caused by RPGs launched towards a vehicle. The bar armor system includes at least one bar array, comprised of lateral bars and vertical bars, wherein the lateral bars are set in predetermined positions so as to reduce the possibility of shaped charges being directed towards the target vehicle. Tubular shaft retainers are provided to be positioned in annular openings in the vertical bars. The lateral bars can be of a round or hexagonal cross-section, and when hexagonal lateral bars are employed, the flat surfaces of the cross-section are positioned horizontally by the tubular shaft retainers so as to minimize the area presented to an oncoming RPG, particularly when the RPG strikes at a non-normal incidence. Push washers can be employed at the outside surfaces of the vertical bars so as to hold them in position. A mounting system is provided that is capable of positioning the bar armor system at close distances to the vehicle so that the overall size and weight of the vehicle is not unduly increased by the bar armor system. The mounts can include rotary latches to provide easy installation and removal. The system can also be of an electrically-conductive unified composition so that efficient electrostatic coating techniques can be used to cover the system. The system can also be provided in the form of kits for ready installation and for more economical repair.

The present invention is directed to isolated nucleic acid molecules encoding a voltage gated sodium channel of a peripheral nerve cell, as well as to the isolated voltage gated sodium channels of a peripheral nerve cell encoded thereby. Methods for increasing or decreasing the expression of functional voltage gated sodium channels in host cells are also provided, as well as methods using the sodium channels. Also provided is a method for isolating other voltage gated sodium channels.

A tool that seats and cuts multiple wires inserted into terminals of a multi-terminal jack includes a support housing for a linearly translatable, and removable carrier. The carrier fixedly retains one of a blade head and a jack, and slidably retains the other of the jack and the blade head, in such a manner that the jack is maintained in precision alignment with the blade head as the carrier is linearly translated within the support housing. A carrier translation control mechanism is coupled to the support housing in a manner that pushes and thereby linearly translates the carrier, so as to bring the blades of the translated blade head into precise stuffing and cutting engagement with the wires in the jack.

A robotic arm-end gripping device having a belt-driven drive train is provided. The gripping device includes a set of opposing gripping arms, a variable speed motor, a motor controller adapted to control the operation of the variable speed motor, a drive train driven by the variable speed motor, the drive train comprising a drive belt, a plurality of sheaves, and a plurality of belt clamps mounted to the drive belt and operatively connected to the opposing gripping arms, and a robot arm-end interface. The gripping device may include a fail-safe method and apparatus for prevent the dropping of the gripped article. The belt drive and associated controls provide smooth and rapid operation. The gripping device may be adapted to any arm-end tooling.

The invention relates to a system for stable maintenance of a plasmid, to host cells for use in this system and to methods of using the system to obtain a plasmid useful in medical applications. In particular, the invention provides transformed host cell containing: i) a chromosomal gene which inhibits cell growth; and ii) a plasmid encoding an antisense sequence, wherein the antisense sequence encoded by the plasmid inhibits the action of the chromosomal gene, thereby permitting cell growth and a method for stable maintenance of a plasmid in a host cell in vivo.

Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

The cable system includes a cable, cable anchors and / or cable crimps. The cable anchors and cable crimps have mounting holes that are used to secure the cable anchors and cable crimps to bones of patients with bone screws. Once the cable anchors and / or cable crimps are attached to the bone, the cable wrapped around the bone and placed through the cable anchors and cable crimps. The cable is tensioned and a locking mechanism is used to lock the cable crimp to the cable. The cable anchors and cable crimps prevent the cable from moving on the bone.

A rod brake, and a method, including an elastic device, such as a coil spring, array of split rings, or an elastic sleeve, that engages one or more grooves in a cylindrical surface to restrain the rod from longitudinal movement relative to another body, and wherein longitudinal force is applied to distort the elastic device and push it out of the one or more grooves to release the rod for longitudinal movement is disclosed. A locking sleeve is added to lock the elastic device against distortion and movement to the release configuration.

Cell transformation vectors for inhibiting HIV and tumor growth are provided. Optionally, the vectors encode RNAses such as EDN. Cells transduced by the vectors and methods of transforming cells (in vitro and in vivo) using the vectors are also provided.

This invention relates to novel uses of a protein sequence (INSP052EC), herein identified as an immunoglobulin domain-containing cell surface recognition, in the diagnosis, prevention and treatment of diseases, in particular those related to the excessive expression and / or secretion of cytokines.

This invention discloses and claims novel proteins, termed KIAA0301, G7c, KIAA0564, NG37, CAB01991.1 and Rv0368c, herein identified as adhesion molecules. Also disclosed and claimed are methods of use of these proteins, and nucleic acid sequences from the encoding genes, in the diagnosis, prevention and treatment of disease.

This invention relates to a novel protein (INSP052), herein identified as an immunoglobulin domain-containing cell surface recognition molecule and to the use of this proteins and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease. The invention also relates to the identification of the extracellular domain of INSP052.

The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of Musca domestica, the VSSC being capable of conferring insecticide susceptibility or insecticide resistance to Musca domestica, as well as to the isolated voltage-sensitive sodium channels of Musca domestica encoded thereby. Nucleic acid molecules encoding insecticide susceptible VSSCs and nucleic acid molecules encoding insecticide resistant VSSCs are provided. Methods for increasing or decreasing the expression of functional voltage-sensitive sodium channels in host cells are also provided, as well as methods using the sodium channels. Also provided is a method for isolating other voltage-sensitive sodium channels.

The invention is based on the discovery that INSP100 is a splice variant of human chorionic somatomammotropin hormone 2 (HCS-B; Q14407) and that INSP104 is a splice variant of human chorionic somatomammotropin hormone 1 (hCS-A;P01243). The invention relates to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease. This invention relates to novel proteins, termed INSP100 and INSP104, herein identified as novel splice variants of human Chorionic somatomammotropin hormone 2 (hCS-B; Q14407) and human Chorionic somatomammotropin hormone 1 (hCS-A; P01243) respectively and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease. The variants have an altered A-B loop and are therefore predicted to possess altered receptor binding properties. All publications, patents and patent applications cited herein are incorporated in full by reference.

The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients.

A shroud lock for locking a position of a needle shroud relative to a housing of an autoinjector, includes a shroud beam arranged on the needle shroud and biased radially outwards, a stop arranged within the housing, a recess arranged proximal of the stop, and a cap coupled to the housing and adapted to prevent distal translation of the needle shroud relative to the housing. At least a portion of the shroud beam is within the recess when the cap is in place and, the shroud beam abuts the stop after the needle shroud is locked relative to the housing of the autoinjector. The disclosure further relates to an autoinjector and to a method for assembling such an autoinjector.

The invention provides isolated N-methyl-D-aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further provided are methods for detecting excitatory glycine receptor ligands, agonists and antagonists. The invention also provides related diagnostic and therapeutic methods.

A method of modulating differentiation or neoplastic transformation of cells is provided in which the cells are caused to increase or decrease cad-11 expression or function. Such method has application in affecting differentiation or neoplastic transformation of cells, preventing or terminating pregnancy by altering cad-11 function or expression in trophoblast cells, or for reducing the viability of carcinoma cells having a low to moderate metastatic potential. The use of agents which increase or decrease cad-11 expression or function is also provided, including such use for preparation of medicaments for modulating differentiation or neoplastic transformation of cells. A method for assessing the metastatic potential of carcinoma cells is also provided.

Methods and compositions for reducing the activity or number of memory Th17 cells in ocular tissue, and for treatment and / or prevention of ocular immunoinflammatory diseases are described.

This invention relates to antisense oligonucleotides comprising at least one N3′→P5′ phosphorodiamidate linkage (NPN) in the backbone as well as methods for using the same. The antisense oligonucleotides can effectively prevent or decrease protein expression.