The invention discloses architectural indoor putty capable of purifying air, inhibiting bacteria and repelling mosquitoes and a preparation method of the architectural indoor putty. The putty cream can release air negative ions for a long time, purify the air and contribute to human health, has certain effects of inhibiting and killing staphylococcus, Escherichia coli, gram positive bacteria and multiple pathogenic bacteria and fungi, is aromatic in smell, has the effects of refreshing, invigorating and relieving the pressure, can repel mosquitoes, is high in adhesive force, high in leveling property, difficult to roll, scrubbing-resistant, polish-resistant, difficult to drop, difficult to crack, non-toxic, harmless and non-radioactive, can effectively protect the wall and is organically combined with various coatings. The key point is that the putty does not generate an adverse effect on the human body due to long-term use, is suitable for the crowd at various ages and has wide application prospects.