Methods and constructs including a fixation device and a suture for fixation of soft tissue to bone, or of soft tissue to soft tissue, which amplifies the body's healing response created by the introduction of the suture material and the material properties of the fixation device. Fixation of soft tissue to bone (or of soft tissue to soft tissue) is conducted using a suture (for example, a suture strand, braid, a suture tape, or a combination thereof) and a fixation device (for example, a bone anchor, implant or screw). The suture and fixation device are manufactured from materials that have properties to amplify the body's healing response. Materials such as synthetic bioresorbable polymers (for example, poly-lactic acid) are utilized in the fabrication of orthopedic fixation devices. Once these materials are introduced into the body and are exposed to in vivo conditions, the devices manufactured with these materials undergo hydrolysis and degrade while maintaining specific mechanical properties over time.