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59 results about "Annotation database" patented technology

Pathogenic microorganism metagenome detection method based on third-generation sequencing

The invention discloses a pathogenic microorganism metagenome detection method based on third-generation sequencing, the method comprises the following steps: acquiring original gene detection data of third-generation sequencing of a sample, removing interference sequences, and retaining non-human data; establishing a mapping relationship between the whole species nucleic acid database and the whole species classification database; removing invalid mapping relationships in the mapping relationship set to obtain an effective mapping relationship set of the non-human source data and the whole species classification database, and performing calculation according to the effective mapping relationship set to obtain a species identification result; constructing a microorganism annotation database to obtain microorganism annotation information; constructing a microbial drug resistance database to obtain microbial drug resistance information; and obtaining a microorganism detection report according to the species identification result, the microorganism annotation information and the microorganism drug resistance information. According to the method, the non-human source data is established, the mapping result is optimized, the detection precision is improved, the accuracy of species classification in similar regions is improved, and then species are obtained through prediction and comparison of sequence results.
Owner:成都博欣医学检验实验室有限公司

Annotation database index structure, method for quickly annotating genetic variation and system

The invention provides an index structure of a genome function annotation database, a method for quickly annotating a genetic variation and a system. The index structure comprises a first-grade indexfile based on an annotation database, and a second-grade index file based on the first-grade index file. The first-grade index file comprises a plurality of file blocks. Each file block is composed ofa head and a body. The body is composed of a plurality of lines of compressed data. Each file block corresponds with one compressed block of the annotation database. The second-grade index file is composed of a plurality of lines of data. Each line of data store the position interval of the body data of one file block in the first-grade index file, and a 64-bit virtual file address which can directly address the file block. According to the annotation method, the file address of the data line with the result is found through scanning the two-grade index file, and the annotation database is positioned according to the file address for extracting annotation information and performing annotation on the genetic variation. Compared with direct scanning to the annotation database, the index structure has advantages of greatly reducing magnetic disk reading operations and improving searching speed.
Owner:深圳市泰尔迪恩生物信息科技有限公司
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