30 results about "Complete blood count" patented technology

A method of using a variable set from complete blood counts and blood chemistry panels to generate a machine learned algorithm for determining the effectiveness of thiopurine treatment on inflammatory bowel disease (IBD) patients using CART, boosted trees, random forest classification, RuleFit and / or logistic regression analysis.

Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.

The disclosure relates to devices and methods for analyzing blood cells in a sample. In various embodiments, the present disclosure provides devices and methods of performing complete blood count (CBC) testing. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and / or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing blood cells in a sample.

The invention discloses an intelligent blood collection device, which comprises a box body, a vacuum storage blood vessel, and a blood collection tube. There is a control panel. When in use, the blood collection tube is connected to the vacuum storage vessel and the blood collector. A capacity detection device is installed at the vacuum storage vessel, and an alarm device is also provided on the box body. The control panel controls the capacity detection device and the blood collector. An alarm device, when the required blood volume is reached, the alarm device will alarm to complete the blood collection. The device can detect the amount of blood collected and actively collect blood samples during blood collection, reducing the workload of medical staff. In addition, the device can also record and transmit patient information, one-time information collection, and prevent errors.

Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent / stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.

This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting and analyzing blood cells in biological samples. A small measured quantity of a biological sample, such as whole blood, is placed in a mixing bowl on the disposable test cartridge after being inserted into the cell analyzer. The analayzer also deposits a known amount of diluent / stain in the mixing bowl and mixes it with the blood. The analyzer takes a measured amount of the mixture and dispenses in a sample cup on the cartridge in fluid communication with an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping as it is transferred into the imaging chamber by the analyzer. Images of all of the cellular components within the imaging chamber are counted and analyzed to obtain a complete blood count.

A device for full blood count includes first channel and second channels separated from each other. The device further includes a first inlet configured to provide a whole blood sample to the first and second channels, a second inlet configured to provide a lysis agent for white blood cell count in to the first channel, a third inlet configured to provide a quench solution to the first channel, and a fourth inlet configured to provide a lysis agent for hemoglobin measurement to the second channel.

The invention provides an eliminating method of interference of the measurement of hypertriglyceride to the concentration of hemoglobin, comprising the following steps of: (1) carrying out complete blood count to blood containing the hypertriglyceride and obtaining the measuring value, HGB lipemia, of the concentration of the hemoglobin and the hematocrit, HCT lipemia, of the erythrocyte; (2) carrying out low-speed centrifugation to the blood containing the hypertriglyceride in the step (1) and leading the erythrocyte and the blood plasma in the blood to be separated; (3) aspirating the bloodplasma separated out in the step (2), carrying out complete blood count to the blood plasma and obtaining the measuring value, HGB lipemia blood plasma, of the concentration of the hemoglobin in the blood plasma; and (4) carrying out correction to the measuring value, HGB lipemia, of the concentration of the hemoglobin obtained in the step (1), obtaining the corrected value of the concentration of the hemoglobin and the corrective formula is as follows: HGB corrected value is equal to HGB lipemia-(HGB lipemia blood plasma minus HGB lipemia blood plasma multiplied by HCT lipemia), in the formula, the HGB lipemia blood plasma multiplied by HCT lipemia is the percentage of the erythrocyte in the blood containing the hypertriglyceride.

The invention discloses a mechanical sampling system of a dry-type blood cell analyzing device. The mechanical sampling system comprises a sampling groove 2, a capillary tube 4, a base 11, a supporting table 15, horizontal sliding rails 12, a spring clip 14, a bearing 16, a grip 18, a linear motor 13 for propulsion, a linear motor 17 for rotation, a permanent seat of the linear motor for propulsion, a permanent seat of the linear motor for rotation and a bearing permanent seat. The mechanical sampling system is suitable for the sampling of a complete blood cell analyzing device, is simple in structure and has good shock resistance, fast analysis speed and stable performance.

The invention relates to the field of biotechnology, in particular to the application of complete blood count in predicting SARS-CoV-2 infection. The invention implements various models, applies decision tree, K-nearest neighbor algorithm, support vector machine and Naive Bayes for classification , these models can predict SARS‑CoV‑2, among which the AUC of non-hospitalized patients in the decision tree model can reach up to 90%, and the data of comprehensive inpatients in the support vector machine model can reach 96%, the present invention not only uses from Data collected from normalized complete blood counts were also compared with studies on the same dataset but using different models, which showed that support vector machines and decision trees outperformed models used in published studies, which can be useful in disease Early stages of manifestations use biomarkers for initial screening between SARS‑CoV‑2 positivity and negativity, the different parameters of the complete blood count are of great value and appeal due to their simplicity and easily measurable parameters.

Methods are described for identifying CDI patients as well as CDI patients at risk for recurrence. Embodiments include: (1) flow cytometry of circulating peripheral blood mononuclear cells (PBMC) to phenotype for the less efficient immunoglobulin response to bacterial toxins and surface antigens that characterizes patients who will become recurrent; (2) stratification by means of complete blood count (CBC) using a Coulter counter to detect the differences in lower angle light scatter (LAL), which has a larger range in the recurrent population; and (3) stratification by means of complete blood count (CBC) using a Coulter counter to detect the lower axial light loss (AL2) exhibited in recurrent patients.

The invention discloses an optical detection system of a dry-type blood cell analyzing device. The optical detection system of the dry-type blood cell analyzing device comprises a red light source 5, a blue light source 7, a lens 8 and a colored linear array CCD (Charged Coupled Device) imaging sensor 9, wherein the two light sources are used for sequentially irradiating a to-be-detected capillary tube, the lens 8 is used for imaging the capillary tube, the colored linear array CCD imaging sensor 9 is used for collecting images, and complete blood cell counting results are obtained through data processing. The optical detection system is suitable for the optical detection of a complete blood cell analyzing device, is fast in speed and has stable performances.