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40 results about "Diverse population" patented technology
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What is Diverse Population. 1. A variety of people which include several characteristic “against” what one may deem as the norm or majority.
Methods for detection and quantification of analytes in complex mixtures
InactiveUS7473767B2Sugar derivativesMaterial analysis by observing effect on chemical indicatorAnalyteNucleic Acid Probes
The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid. Also provided is a method of producing a population of uniquely labeled nucleic acid probes. The method consists of (a) synthesizing a population of target specific nucleic acid probes each having a different specifier; (b) synthesizing a corresponding population of anti-genedigits each having a unique label, the population having a diversity sufficient to uniquely hybridize to genedigits within the specifiers, and (c) hybridizing the populations of target nucleic acid probes to the anti-genedigits, to produce a population in which each of the target specific probes is uniquely labeled. Also provided is a method of detecting a nucleic acid analyte.
Owner:INSTITUTE FOR SYSTEMS BIOLOGY
Methods for producing members of specific binding pairs
InactiveUS7063943B1Simple procedureSpeedSugar derivativesMicrobiological testing/measurementFree formGenetic diversity
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods.
Owner:MEDIMMUNE LTD
Methods for detection and quantification of analytes in complex mixtures
InactiveUS20070166708A1Sugar derivativesMaterial analysis by observing effect on chemical indicatorAnalyteNucleic Acid Probes
The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid. Also provided is a method of producing a population of uniquely labeled nucleic acid probes. The method consists of (a) synthesizing a population of target specific nucleic acid probes each having a different specifier; (b) synthesizing a corresponding population of anti-genedigits each having a unique label, the population having a diversity sufficient to uniquely hybridize to genedigits within the specifiers, and (c) hybridizing the populations of target nucleic acid probes to the anti-genedigits, to produce a population in which each of the target specific probes is uniquely labeled. Also provided is a method of detecting a nucleic acid analyte. The method consists of (a) contacting a mixture of nucleic acid analytes under conditions sufficient for hybridization with a plurality of target specific nucleic acid probes each having a different specifier; (b) contacting the mixture under conditions sufficient for hybridization with a corresponding plurality of anti-genedigits each having a unique label, the plurality of anti-genedigits having a diversity sufficient to uniquely hybridize to genedigits within the specifiers, and (c) uniquely detecting a hybridized complex between one or more analytes in the mixture, a target specific probe, and an anti-genedigit.
Owner:INSTITUTE FOR SYSTEMS BIOLOGY
Method of generating an optimized, diverse population of variants
The present disclosure relates to methods of rapidly and efficiently searching biologically-related data space to identify a population set maximally diverse and optimized for sets of desired properties. More specifically, the disclosure provides methods of identifying a diverse, evolutionary separated bio-molecules with desired properties from complex bio-molecule libraries. The disclosure additionally provides digital systems and software for performing these methods.
Owner:CODEXIS INC
Method of generating an optimized, diverse population of variants
The disclosure relates to a method of generating a diverse set of variants to screen improved and novel properties within the variant population, a system for creating the diverse set of variants, and the variant peptides.
Owner:CODEXIS INC
Optical method and system for rapid identification of multiple refractive index materials using multiscale texture and color invariants
ActiveUS20050126505A1Rapid and accurate identificationRapid and accurate and classificationClimate change adaptationCharacter and pattern recognitionGabor wavelet transformFeature set
An innovative optical system and method is disclosed for analyzing and uniquely identifying high-order refractive indices samples in a diverse population of nearly identical samples. The system and method are particularly suitable for ultra-fine materials having similar color, shape and features which are difficult to identify through conventional chemical, physical, electrical or optical methods due to a lack of distinguishing features. The invention discloses a uniquely configured optical system which employs polarized sample light passing through a full wave compensation plate, a linear polarizer analyzer and a quarter wave retardation plate for producing vivid color bi-refringence pattern images which uniquely identify high-order refractive indices samples in a diverse population of nearly visually identical samples. The resultant patterns display very subtle differences between species which are frequently indiscernable by conventional microscopy methods. When these images are analyzed with a trainable with a statistical learning model, such as a soft-margin support vector machine with a Gaussian RBF kernel, good discrimination is obtained on a feature set extracted from Gabor wavelet transforms and color distribution angles of each image. By constraining the Gabor center frequencies to be low, the resulting system can attain classification accuracy in excess of 90% for vertically oriented images, and in excess of 80% for randomly oriented images.
Owner:WOODS HOLE OCEANOGRAPHIC INSTITUTION
Methods for detection and quantification of analytes in complex mixtures
InactiveUS20090220978A1Material analysis by observing effect on chemical indicatorMicrobiological testing/measurementAnalyteNucleic Acid Probes
Owner:INSTITUTE FOR SYSTEMS BIOLOGY
Methods for producing members of specific binding pairs
InactiveUS7662557B2Simple procedureSpeedImmunoglobulins against blood group antigensAntibody mimetics/scaffoldsGenetic diversityDna encoding
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA.
Owner:MEDIMMUNE LTD
Assessment and Enhancement of Reaction Based Joint Stabilization Capabilities
ActiveUS20180304118A1Stable and accurateEfficient solutionHealth-index calculationDiagnostic recording/measuringEngineeringCvd risk
Interactive system provides training and assessments relating to joint stabilization capabilities and reaction-based performance for diverse populations. This system may enhance the subject's ability to generate and deliver power as a direct byproduct of properly timed decelerations originating with the effectors and supported by the verticality of the spine. Said decelerations also provide functional means for improving joint stabilization capabilities via improved co-contraction of the shoulder(s) joints and other anatomical locations on the subject. The resulting data may serve as the basis for predictive analytics relating to joint stabilization and the associated risk of orthopedic injuries. This system may also train / improve the dampening of internal forces resulting from aggressive weight bearing movements, and more effectively dissipate the force of received physical impacts.
Owner:FRENCH FAMILY TRUST
Population Adjusted Indexes
InactiveUS20110060603A1Evaluate performanceDigital data information retrievalFinanceComputerized systemCrowds
Articles of manufacture including electronic machines including but not limited to computers, computer stations, computing devices, computer systems, software, computer readable memory and other electronic devices adapted to provide an index for a performance characteristic or measure for groups of people or institutions. The index values are risk adjusted to the varying population compositions for groups of people or institutions by comparison to a reference portfolio and are updated in real time to account for the changing constitution of the clusters in the portfolios. Methods of using the disclosed devices include the ability to provide a continuously updated benchmark for the comparison of medical, business or educational performance by providers or practitioners of such services that effect populations of individuals, and that is based on measurable outcomes. Additionally, the methods of using the disclosed devices include the ability to compare the effectiveness of different therapies.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Wearable transdermal neurostimulator having cantilevered attachment
Neurostimulator apparatuses for applying transdermal electrical stimulation that may be comfortably and securely worn on a variety of head shapes and sizes. The apparatuses and methods of using them described herein may be lightweight and wearable and configured to be attached at one end of a patient-facing surface of the apparatus by a cantilevered attachment so that an opposite end of the surface is free to float relative to the user's head. The cantilevered attachment may include two or more connectors spaced apart along an edge region of the patient-facing surface in an optimal arrangement to secure the neurostimulator in place. The neurostimulator apparatuses described herein may be secured to a separate or integral electrode assembly that may adhesively secure to the subject's head. The patient-facing surface of the neurostimulator may also be curved and twisted specifically for use at the temple / forehead region of a diverse population of potential users.
Owner:THYNC GLOBAL INC
Polyvalent display libraries
InactiveUS6986986B1Antibody mimetics/scaffoldsMicrobiological testing/measurementENCODEDiverse population
The invention is directed to inter alia two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display libraries for members displaying more than one copy of a polypeptide prior to affinity screening of such libraries with a target of interest. These methods can achieve diverse populations in which the vast majority of members retaining full-length coding sequences encode polypeptides having specific affinity for the target. In a second aspect, the invention provides methods of subcloning nucleic acids encoding displayed polypeptides of enriched libraries from a display vector to an expression vector without the need for clonal isolation of individual members. These methods result in polyclonal libraries of antibodies and other polypeptides for use, e.g., as diagnostic or therapeutic reagents.
Owner:BIOSITE INC
Establishing an Inventory Management and Trading Application for Alternative, Illiquid Repurchase Agreement Markets
InactiveUS20110270735A1High percentage of matchImprove liquidityFinanceInventory managementDiverse population
The invention relates to a system and method for repo trading. The invention facilitates the inventory collection, organization, and search of the long and short positions of financial instruments such as corporate bonds and equities through the provision of a database. The invention also provides users with the ability to match borrowers and lenders with opposing positions for financial instruments. In a second embodiment the invention provides a system for creating pseudo-securities, from a diverse population of corporate bonds or equities that meet parameters specified by a user.
Owner:INTERCAPITAL SERVICES NORTH AMERICA LLC
Laser isolation of viable cells
Methods for laser microdissection isolation of viable cells are provided. Cells of a desired type may be isolated from a diverse population, optionally with detection and exclusion of undesired cells. Desired cells may be isolated from a population that arose from differentiation of pluripotent cells, preferably embryonic stem cells or induced pluripotent stem cells, and undifferentiated stem cells may be detected and excluded from selection including the isolation of RPE cells sleeted based on morphology (e.g., characteristic mottled appearance) from a population of ES cells. The cells isolated by these methods, including RPE cells, may be essentially free of undifferentiated cells and thus suitable for use in cell-based therapies.
Owner:ADVANCED CELL TECH INC
Prediction of HCV Viral Kinetics in Interferon-Free Treatment
InactiveUS20120196272A1Reduce the possibilityShort durationOrganic active ingredientsMicrobiological testing/measurementMedicineInterferon alpha
The present invention is based on the discovery of associations that exist between single nucleotide polymorphisms (SNPs) on chromosome 19 and virological outcomes in a diverse population of patients with hepatitis C virus (HCV) who received interferon-free treatment.
Owner:ROCHE MOLECULAR SYST INC
Single Nucleotide Polymorphism on Chromosome 15 That Predicts HCV Treatment Responses
InactiveUS20130137084A1Raise the possibilityMicrobiological testing/measurementAntiviralsHcv treatmentDiverse population
The present invention is based on the discovery of associations that exist between single nucleotide polymorphisms (SNPs) on chromosome 15 and virological outcomes in a diverse population of patients with hepatitis C virus (HCV) who received interferon-based treatment.
Owner:ROCHE MOLECULAR SYST INC
Population identification method and system based on mobile phone signaling data
ActiveCN109992605AImprovement of recognition progressDigital data information retrievalLocation information based serviceTime segmentDiverse population
The invention discloses a population identification method and system based on mobile phone signaling data. The population identification method comprises the following steps: respectively setting target time periods of a tourism light season and a tourism vigorous season for a target area; respectively selecting target users of which the residence time of the target area exceeds a first time threshold in two target time periods through the mobile phone signaling data of the users; counting the number of staying days of each target user in the target area, detecting the number of staying days,and dividing permanent resident population, seasonal resident population, tourist population, other population and working population. According to the method, different population types can be accurately identified, the actual service population composition of a city is truly reflected, and a basis is provided for scientific city planning and decision making.
Owner:SHANGHAI TONGJI URBAN PLANNING & DESIGN INST
Establishing an Inventory Management and Trading Application for Alternative, Liquid Repurchase Agreement Markets
The invention relates to a system and method for repo trading. The invention facilitates the inventory collection, organization, and search of the long and short positions of financial instruments such as corporate bonds and equities through the provision of a database. The invention also provides users with the ability to match borrowers and lenders with opposing positions for financial instruments. In a second embodiment the invention provides a system for creating pseudo-securities, from a diverse population of corporate bonds or equities that meet parameters specified by a user.
Owner:INTERCAPITAL SERVICES NORTH AMERICA LLC
Optical method and system for rapid identification of multiple refractive index materials using multiscale texture and color invariants
ActiveUS7415136B2Improve discriminationFinish quicklyClimate change adaptationCharacter and pattern recognitionGabor wavelet transformFeature set
An innovative optical system and method is disclosed for analyzing and uniquely identifying high-order refractive indices samples in a diverse population of nearly identical samples. The system and method are particularly suitable for ultra-fine materials having similar color, shape and features which are difficult to identify through conventional chemical, physical, electrical or optical methods due to a lack of distinguishing features. The invention discloses a uniquely configured optical system which employs polarized sample light passing through a full wave compensation plate, a linear polarizer analyzer and a quarter wave retardation plate for producing vivid color bi-refringence pattern images which uniquely identify high-order refractive indices samples in a diverse population of nearly visually identical samples. The resultant patterns display very subtle differences between species which are frequently indiscernable by conventional microscopy methods. When these images are analyzed with a trainable with a statistical learning model, such as a soft-margin support vector machine with a Gaussian RBF kernel, good discrimination is obtained on a feature set extracted from Gabor wavelet transforms and color distribution angles of each image. By constraining the Gabor center frequencies to be low, the resulting system can attain classification accuracy in excess of 90% for vertically oriented images, and in excess of 80% for randomly oriented images.
Owner:WOODS HOLE OCEANOGRAPHIC INSTITUTION
Prediction of Early Virological Response in HCV Treatment
InactiveUS20120094284A1Raise the possibilityShort durationMicrobiological testing/measurementBiological testingHcv treatmentMedicine
The present invention is based on the discovery of associations that exist between single nucleotide polymorphisms (SNPs) on chromosome 19 and virological outcomes in a diverse population of patients with hepatitis C virus (HCV) who received interferon-based treatment.
Owner:ROCHE MOLECULAR SYST INC
Method of generating an optimized, diverse population of variants
ActiveUS20110029468A1Increase probabilityHigh degreeDigital computer detailsBiostatisticsBio moleculesData space
The present disclosure relates to methods of rapidly and efficiently searching biologically-related data space to identify a population set maximally diverse and optimized for sets of desired properties. More specifically, the disclosure provides methods of identifying a diverse, evolutionary separated bio-molecules with desired properties from complex bio-molecule libraries. The disclosure additionally provides digital systems and software for performing these methods.
Owner:CODEXIS INC
Methods for Predicting Responses to Chemical or Biological Substances
InactiveUS20160146789A1MinimizeGood of toxic responseMicrobiological testing/measurementBiological testingGenetic diversityDiverse population
Methods for predicting differential human responses to chemical and biological substances using extra-embryonic pluripotent or multipotent stem cells from at least 20 different donors. In one embodiment, the extra-embryonic pluripotent or multi-potent stem cells are differentiated. The method is useful for predicting and elucidating differential human responses to chemical and biological substances in vitro across a genetically diverse population.
Owner:COYNE SCI
Immunoglobulin-like variable chain binding polypeptides and methods of use
InactiveUS20060263787A1Good curative effectUndesirable side-effectMicrobiological testing/measurementImmunoglobulins against cytokines/lymphokines/interferonsExonDiverse population
The invention provides an isolated diverse population of VH-like binding polypeptides. Each binding polypeptide within the population comprising an unascertained combination of an immunoglobulin VH region exon encoded polypeptide, a JH region exon encoded polypeptide and a D region exon encoded polypeptide, wherein the VH, D and JH region exon encoded polypeptides are joined in a single polypeptide forming an immunoglobulin VH-like binding polypeptide, or a functional fragment thereof.
Owner:EVANS GLEN A +1
Wearable transdermal neurostimulator having cantilevered attachment
ActiveUS20150335875A1Weight optimizationExternal electrodesArtificial respirationEngineeringForehead
Neurostimulator apparatuses for applying transdermal electrical stimulation that may be comfortably and securely worn on a variety of head shapes and sizes. The apparatuses and methods of using them described herein may be lightweight and wearable and configured to be attached at one end of a patient-facing surface of the apparatus by a cantilevered attachment so that an opposite end of the surface is free to float relative to the user's head. The cantilevered attachment may include two or more connectors spaced apart along an edge region of the patient-facing surface in an optimal arrangement to secure the neurostimulator in place. The neurostimulator apparatuses described herein may be secured to a separate or integral electrode assembly that may adhesively secure to the subject's head. The patient-facing surface of the neurostimulator may also be curved and twisted specifically for use at the temple / forehead region of a diverse population of potential users.
Owner:THYNC GLOBAL INC
Methods for producing members of specific binding pairs
InactiveUS20070148774A1Simple procedureSpeedImmunoglobulins against blood group antigensBacteriaGenetic diversityFree form
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods.
Owner:MEDIMMUNE LTD
Enrichment of Tissue-Derived Adult Stem Cells Based on Retained Extracellular Matrix Material
ActiveUS20100167316A1High prevalenceCulture processCell culture supports/coatingCell-Extracellular MatrixECM Protein
Methods for enriching, detecting, or using adult stem cells through the use of recognition ligands that specifically bind to ECM components retained to the surfaces of adult stem cells are described. An ECM component such as hyaluronan that is retained to the surfaces of adult stem cells when removed from animal tissues can be used to detect a diverse population of adult stem cells based on the nature of the ECM niche region in which the adult stem cells normally reside. For example, a separation method such as magnetic separation can be used to detect and isolate or enrich adult stem cells based on a recognition ligand that is specific for an ECM component that is retained to the surfaces of adult stem cells to a greater degree than to other cells in the population.
Owner:THE CLEVELAND CLINIC FOUND
Use of a tag to enrich polypeptides libraries
The invention is directed to production of chimeric antibodies using display screening methods. The invention is based in part on two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display libraries for members displaying more than one copy of a polypeptide prior to affinity screening of such libraries with a target of interest. These methods can achieve diverse populations in which the vast majority of members retaining full-length coding sequences encode polypeptides having specific affinity for the target. In a second aspect, the invention provides methods of subcloning nucleic acids encoding displayed polypeptides of enriched libraries from a display vector to an expression vector without the need for clonal isolation of individual members. These methods can be used to produce polyclonal libraries of chimeric antibodies for use, e.g., as diagnostic or therapeutic reagents.
Owner:BIOSITE INC
Management of osteoarthritis using pooled allogeneic mesenchymal stem cells
The present disclosure relates to a composition and method for management of Osteoarthritis, including improvement in pain and cartilage regeneration of knee joint affected by osteoarthritis. The present disclosure also relates to a kit for treating Osteoarthritis and the method of assembling the same. The present disclosure relates to a pooled allogeneic mesenchymal stromal cell composition from multiple donors with diverse HLA genotypes suitable for transplantation into a diverse population without the risk of rejection. The pooled cell composition of the present disclosure shows increased potency and higher chondrogenic differentiation potential.
Owner:STEMPEUTICS RES PRIVATE
Population dynamic measurement and calculation method and system based on urban super-brain computing platform
ActiveCN110704789AUseful for predicting populationData processing applicationsCharacter and pattern recognitionAlgorithmDiverse population
The invention provides a population dynamic measurement and calculation method and system automatically depending on an urban super-brain computing platform. The method comprises the following steps:S1, presetting a population type; s2, establishing an influence degree model of the spatial environment and spatial relationship of the urban spatial region relative to dynamic distribution of different population types; s3, collecting a certain number of samples of a real city space area; s4, respectively training the influence degree models established in the step S2 by utilizing the samples collected in the step S3; and S5, substituting the spatial environment and spatial relationship parameters of any real urban spatial region into the influence degree model trained in the step S4, and obtaining dynamic population distribution of various types in the urban spatial region. Scientific and targeted analysis and judgment of dynamic distribution conditions of different types of population are facilitated, the population quantity of urban space areas is predicted, and population density points are excavated.
Owner:重庆特斯联智慧科技股份有限公司
Epitopes of hepatitis C virus
InactiveUS7201904B2Increased proliferationLow in CD45RABiocideSsRNA viruses positive-senseEpitopeT lymphocyte
The invention provides compositions containing HCV epitopes, which are recognized by cytotoxic T lymphocytes. Such polypeptides are used in prophylactic vaccines, immunotherapies, and assays to monitor the progress or success of immune interventions. The compositions are optimized to elicit an immune response in a genetically-diverse population of individuals.
Owner:THE GENERAL HOSPITAL CORP
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