40 results about "Diverse population" patented technology

An innovative optical system and method is disclosed for analyzing and uniquely identifying high-order refractive indices samples in a diverse population of nearly identical samples. The system and method are particularly suitable for ultra-fine materials having similar color, shape and features which are difficult to identify through conventional chemical, physical, electrical or optical methods due to a lack of distinguishing features. The invention discloses a uniquely configured optical system which employs polarized sample light passing through a full wave compensation plate, a linear polarizer analyzer and a quarter wave retardation plate for producing vivid color bi-refringence pattern images which uniquely identify high-order refractive indices samples in a diverse population of nearly visually identical samples. The resultant patterns display very subtle differences between species which are frequently indiscernable by conventional microscopy methods. When these images are analyzed with a trainable with a statistical learning model, such as a soft-margin support vector machine with a Gaussian RBF kernel, good discrimination is obtained on a feature set extracted from Gabor wavelet transforms and color distribution angles of each image. By constraining the Gabor center frequencies to be low, the resulting system can attain classification accuracy in excess of 90% for vertically oriented images, and in excess of 80% for randomly oriented images.

Interactive system provides training and assessments relating to joint stabilization capabilities and reaction-based performance for diverse populations. This system may enhance the subject's ability to generate and deliver power as a direct byproduct of properly timed decelerations originating with the effectors and supported by the verticality of the spine. Said decelerations also provide functional means for improving joint stabilization capabilities via improved co-contraction of the shoulder(s) joints and other anatomical locations on the subject. The resulting data may serve as the basis for predictive analytics relating to joint stabilization and the associated risk of orthopedic injuries. This system may also train/improve the dampening of internal forces resulting from aggressive weight bearing movements, and more effectively dissipate the force of received physical impacts.

Articles of manufacture including electronic machines including but not limited to computers, computer stations, computing devices, computer systems, software, computer readable memory and other electronic devices adapted to provide an index for a performance characteristic or measure for groups of people or institutions. The index values are risk adjusted to the varying population compositions for groups of people or institutions by comparison to a reference portfolio and are updated in real time to account for the changing constitution of the clusters in the portfolios. Methods of using the disclosed devices include the ability to provide a continuously updated benchmark for the comparison of medical, business or educational performance by providers or practitioners of such services that effect populations of individuals, and that is based on measurable outcomes. Additionally, the methods of using the disclosed devices include the ability to compare the effectiveness of different therapies.

The invention is directed to inter alia two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display libraries for members displaying more than one copy of a polypeptide prior to affinity screening of such libraries with a target of interest. These methods can achieve diverse populations in which the vast majority of members retaining full-length coding sequences encode polypeptides having specific affinity for the target. In a second aspect, the invention provides methods of subcloning nucleic acids encoding displayed polypeptides of enriched libraries from a display vector to an expression vector without the need for clonal isolation of individual members. These methods result in polyclonal libraries of antibodies and other polypeptides for use, e.g., as diagnostic or therapeutic reagents.

Methods for laser microdissection isolation of viable cells are provided. Cells of a desired type may be isolated from a diverse population, optionally with detection and exclusion of undesired cells. Desired cells may be isolated from a population that arose from differentiation of pluripotent cells, preferably embryonic stem cells or induced pluripotent stem cells, and undifferentiated stem cells may be detected and excluded from selection including the isolation of RPE cells sleeted based on morphology (e.g., characteristic mottled appearance) from a population of ES cells. The cells isolated by these methods, including RPE cells, may be essentially free of undifferentiated cells and thus suitable for use in cell-based therapies.

The present invention is based on the discovery of associations that exist between single nucleotide polymorphisms (SNPs) on chromosome 19 and virological outcomes in a diverse population of patients with hepatitis C virus (HCV) who received interferon-free treatment.

The present invention is based on the discovery of associations that exist between single nucleotide polymorphisms (SNPs) on chromosome 15 and virological outcomes in a diverse population of patients with hepatitis C virus (HCV) who received interferon-based treatment.

The invention discloses a population identification method and system based on mobile phone signaling data. The population identification method comprises the following steps: respectively setting target time periods of a tourism light season and a tourism vigorous season for a target area; respectively selecting target users of which the residence time of the target area exceeds a first time threshold in two target time periods through the mobile phone signaling data of the users; counting the number of staying days of each target user in the target area, detecting the number of staying days,and dividing permanent resident population, seasonal resident population, tourist population, other population and working population. According to the method, different population types can be accurately identified, the actual service population composition of a city is truly reflected, and a basis is provided for scientific city planning and decision making.

The invention relates to a system and method for repo trading. The invention facilitates the inventory collection, organization, and search of the long and short positions of financial instruments such as corporate bonds and equities through the provision of a database. The invention also provides users with the ability to match borrowers and lenders with opposing positions for financial instruments. In a second embodiment the invention provides a system for creating pseudo-securities, from a diverse population of corporate bonds or equities that meet parameters specified by a user.

The present invention is based on the discovery of associations that exist between single nucleotide polymorphisms (SNPs) on chromosome 19 and virological outcomes in a diverse population of patients with hepatitis C virus (HCV) who received interferon-based treatment.

The present disclosure relates to methods of rapidly and efficiently searching biologically-related data space to identify a population set maximally diverse and optimized for sets of desired properties. More specifically, the disclosure provides methods of identifying a diverse, evolutionary separated bio-molecules with desired properties from complex bio-molecule libraries. The disclosure additionally provides digital systems and software for performing these methods.

Methods for predicting differential human responses to chemical and biological substances using extra-embryonic pluripotent or multipotent stem cells from at least 20 different donors. In one embodiment, the extra-embryonic pluripotent or multi-potent stem cells are differentiated. The method is useful for predicting and elucidating differential human responses to chemical and biological substances in vitro across a genetically diverse population.

The invention provides an isolated diverse population of V_H-like binding polypeptides. Each binding polypeptide within the population comprising an unascertained combination of an immunoglobulin V_H region exon encoded polypeptide, a J_H region exon encoded polypeptide and a D region exon encoded polypeptide, wherein the V_H, D and J_H region exon encoded polypeptides are joined in a single polypeptide forming an immunoglobulin V_H-like binding polypeptide, or a functional fragment thereof.

Neurostimulator apparatuses for applying transdermal electrical stimulation that may be comfortably and securely worn on a variety of head shapes and sizes. The apparatuses and methods of using them described herein may be lightweight and wearable and configured to be attached at one end of a patient-facing surface of the apparatus by a cantilevered attachment so that an opposite end of the surface is free to float relative to the user's head. The cantilevered attachment may include two or more connectors spaced apart along an edge region of the patient-facing surface in an optimal arrangement to secure the neurostimulator in place. The neurostimulator apparatuses described herein may be secured to a separate or integral electrode assembly that may adhesively secure to the subject's head. The patient-facing surface of the neurostimulator may also be curved and twisted specifically for use at the temple/forehead region of a diverse population of potential users.

Methods for enriching, detecting, or using adult stem cells through the use of recognition ligands that specifically bind to ECM components retained to the surfaces of adult stem cells are described. An ECM component such as hyaluronan that is retained to the surfaces of adult stem cells when removed from animal tissues can be used to detect a diverse population of adult stem cells based on the nature of the ECM niche region in which the adult stem cells normally reside. For example, a separation method such as magnetic separation can be used to detect and isolate or enrich adult stem cells based on a recognition ligand that is specific for an ECM component that is retained to the surfaces of adult stem cells to a greater degree than to other cells in the population.

The invention is directed to production of chimeric antibodies using display screening methods. The invention is based in part on two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display libraries for members displaying more than one copy of a polypeptide prior to affinity screening of such libraries with a target of interest. These methods can achieve diverse populations in which the vast majority of members retaining full-length coding sequences encode polypeptides having specific affinity for the target. In a second aspect, the invention provides methods of subcloning nucleic acids encoding displayed polypeptides of enriched libraries from a display vector to an expression vector without the need for clonal isolation of individual members. These methods can be used to produce polyclonal libraries of chimeric antibodies for use, e.g., as diagnostic or therapeutic reagents.

The invention provides a population dynamic measurement and calculation method and system automatically depending on an urban super-brain computing platform. The method comprises the following steps:S1, presetting a population type; s2, establishing an influence degree model of the spatial environment and spatial relationship of the urban spatial region relative to dynamic distribution of different population types; s3, collecting a certain number of samples of a real city space area; s4, respectively training the influence degree models established in the step S2 by utilizing the samples collected in the step S3; and S5, substituting the spatial environment and spatial relationship parameters of any real urban spatial region into the influence degree model trained in the step S4, and obtaining dynamic population distribution of various types in the urban spatial region. Scientific and targeted analysis and judgment of dynamic distribution conditions of different types of population are facilitated, the population quantity of urban space areas is predicted, and population density points are excavated.

The invention provides compositions containing HCV epitopes, which are recognized by cytotoxic T lymphocytes. Such polypeptides are used in prophylactic vaccines, immunotherapies, and assays to monitor the progress or success of immune interventions. The compositions are optimized to elicit an immune response in a genetically-diverse population of individuals.