The invention belongs to the technical field of
medicine. The invention relates to an ear preparation composition, in particular to an ear preparation composition containing anilinoprofen and application of the ear preparation composition. The invention develops new indications of anilinoprofen in the aspect of
otitis, and further develops an efficient therapeutic pharmaceutical composition, namely the composition containing anilinoprofen and antofloxacin. According to the research of the invention,
ibuprofen has the effect of treating
otitis media and
otitis externa, and also can generate a remarkable synergistic effect with antofloxacin. Experimental data show that the
combined treatment of anilinoprofen and antofloxacin can more comprehensively improve clinical symptoms, the impaired hearing threshold (ABR) of a combined group of mice is recovered to be close to a
normal level, scores on indexes such as ear grasping frequency, tympanic membrane hyperemia, tympanic
effusion / external auditory meatus red and swollen are the lowest, and diseases are thoroughly controlled. The composition disclosed by the invention can be prepared into ear drops and other external dosage forms, can directly act on an
inflammation part, is high in targeting property, does not need to be orally taken, and is higher in medication safety.