Disclosed herein are compositions and methods for eyelid cleansing and treatment of ocular conditions. The method of treating an ocular condition involves cleansing the eyelids with a first ophthalmic composition consisting essentially of water, PEG-80 sorbitan laurate, methylgluceth-20, PEG ‑120 Methyl Glucose Dioleate, Salicyl Phytosphingosine, Decyl Glucoside, 1,2‑Hexanediol, Caprylyl Glycol, Disodium Cocoamphodiacetate, Panthenol, Polyaminopropyl biguanide, sodium chloride, potassium chloride, and calcium chloride; and then applying a therapeutically effective amount of a second ophthalmic composition to the eyelid margin, wherein the second ophthalmic composition consists essentially of water and hypochlorous acid.