The invention belongs to the technical field of safety communication, and discloses a controlled quantum safe and direct communication method and system for preventing tampering. A receiving end is controlled to obtain secret information of a sending end, and the sending end sends SC* to a control end; the control end disorganizes photons in SC*; then the control end sends rearranged SC* to the receiving end; if the control end does not tell the accurate sequence of the photons to the receiving end, the receiving end cannot resume SC and decrypt the secret information; the control end cannot know the secret information encrypted through K(k1, k2, ..., kN). The premise that a controller is honest is not needed; even under the condition that the controller is dishonest, the proposed protocolis still safe, and any tampering of the secret information can be easily found. By means of the controlled quantum safe direct communication method and system for preventing tampering, attack of fakephotons based on quantum teleportation can be resisted, and meanwhile, identities of two participants, namely, the sender and the receiver, can also be verified.