The invention discloses a quantum secure direct communication protocol based on the three-particle GHZ entangled state. Alice prepares N groups of particles in the GHZ entangled state, and a sequence C'2 is sent to Bob; the Bob conducts single practical measurement on a sequence A21 and a sequence B21, the Alice conducts single practical measurement on a sequence C21, and it is determined that wiretapping exists if results of two measurements do not meet the corresponding relation; if the results of the two measurements meet the corresponding relation, A1 and B1 are encoded, particles in a sequence A22 and a sequence B22 are inserted into the A1 and the B1, the order of the particles is disrupted, and a sequence C'3 is generated and sent to the Bob; the Bob conducts single practical measurement on the sequence A22 and the sequence B22, the Alice conducts single practical measurement on a sequence C22, and it is determined that wiretapping exists if results of two measurements do not meet the corresponding relation; if the results of the two measurements meet the corresponding relation, the Bob conducts combined measurement on the A1, the B1 and a C1, and the information sent by the Alice is obtained. According to the quantum secure direct communication protocol based on the three-particle GHZ entangled state, the QSDC communication safety can be effectively improved, and the error detection rate reaches up to 62.5%.