A Method for the treatment of
skin fibrosis with
a peptide that inhibits TGF-β, and suitable compositions for its administration. The method includes in particular, the use of
peptide P144, a compound that is a known inhibitor of TGF-β, for the treatment of
skin fibrosis by topical application. The method is shown effective in an
animal model of
bleomycin-induced
skin sclerosis, to a reduction both of the skin
fibrosis and of the content of soluble collagen, without any signs of
systemic toxicity being detected. This shows that P144 is effective for topical application in mammals for treating fibrotic skin diseases and
pathological scarring of the skin. For the administration of this
peptide, stable compositions are also supplied, with pleasant appearance without being greasy, with good spreading characteristics and with a
viscosity that permits it to be processed easily in industrial
plant, and which are suitable for administering the
peptide to humans.