49results about How to "Guaranteed long-term security" patented technology

The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds (e.g., isomers, enantiomers, racemic compounds, metabolites, derivatives, pharmaceutically acceptable salts, in combination with acids or bases, and the like) and methods of using these compounds as antagonists of the anti-apoptotic effects of Bcl-2 family member proteins (e.g., Bcl-2, Bcl-XL, and the like). The present invention also provides compositions comprising gossypol compounds and optionally one or more additional therapeutic agents (e.g., anticancer/chemotherapeutic agents). The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases) comprising administering a composition comprising gossypol compounds and optionally one or more additional therapeutic agents (e.g., anticancer/chemotherapeutic agents) and/or techniques (e.g., radiation therapies, surgical interventions, and the like) to a subject or in vitro cells, tissues, and organs.

The invention relates to a device and the method for detecting the prior project quality. The anchorage cable long-term pre-stress state and the bearing performance are detected through the specific stretching program and the technical proposal; aiming at the situation of the most prior anchorage projects that the steel stranded wires at the end of the anchorage cable end are sheared off, a device for detecting the prior anchorage project quality is designed in the invention, the residual steel stranded wires at the end of the anchorage cable is prolonged and then stretched, and the project quality is detected according to the detection method of the invention, and through the adopting of the device, the stretching force is reinforced to the prior anchorage project which pre-stress is lost; therefore the invention solves the problem of the post-stage detecting of the drawing force of the anchorage section of the prior anchorage project that the long-term quality hidden danger of the anchorage project is found in advance and prevented, and the invention guarantees the long-term security of the anchorage project and provides an effective solving method.

The invention discloses a shield tunnel pipe piece designing method taking double-liquid synchronous grouting layer performance degradation into consideration. The method comprises a first step of determining different distributing patterns of gel calcium silicate in cement-water glass double liquid based on careful observation and analysis, a second step of calculating occurrence frequency, occupied area proportion and structural effect influence coefficient of the gel calcium silicate in different distributing patterns, a third step of carrying out discount calculation on the mechanical property of the cement-water glass double liquid which is degraded by the gel calcium silicate according to a calculated result, and a fourth step of calculating the internal force and the deformation of a shield tunnel pipe piece lining structure by the adoption of the modified routine method. By means of the method, an accurate and effective evaluation can be carried out on the long-term mechanical property of the cement-water glass double liquid which is degraded by the gel calcium silicate which is a reaction product of the double liquid, then the evaluation is carried out on the long-term safety performance of a tunnel structure and other building structures using the cement-water glass double liquid, the method is used for designing shield tunnel pipe pieces, and the result is realer and more reliable.

The invention discloses a concrete for dams. Every cubic meter of concrete comprises the following raw materials: 700-750kg of sand, 1000-1050kg of gravel, 90-110kg of water, 300-350kg of cement, 100-120kg of fly ash, 6.0-6.5kg of water reducing agent, 65-95kg of air entraining agent, 50-70kg of magnesium chloride solution, 3-5kg of additive and 30-50g of composite rare earth. The invention also discloses a preparation method of the concrete. By adding proper admixtures on the premise of not obviously increasing the cement content, the invention obviously enhances the primary indexes of the concrete, greatly lowers the initial hydration heat of cement, avoids temperature cracking, can be widely used for dam concreting or other mass concreting under different climatic conditions, and has important meanings for enhancing the engineering quality and ensuring the long-term safety of engineering.

An article of headwear includes an inner liner 20, a corrugated shell 24, and an outer shell 26. An impact to headwear causes the corrugated shell to elastically deform, with the shell then returning to its original shape. An arrangement of the corrugations allows ease of manufacturing on a vacuum form or injection mold.

The invention relates to the technical field of pipe connection, in particular to a steel wire fixing structure for the end of a steel wire mesh framework polyethylene composite pipe, and a steel wire mesh framework polyethylene composite pipe connecting structure and method. The steel wire fixing structure for the end of the steel wire mesh framework polyethylene composite pipe is structurally characterized in that an outer steel ring is embedded in the end of the steel wire mesh framework polyethylene composite pipe, a circle of protrusion is arranged on the edge of the outer steel ring, and the protrusion is located on the side away from the edge of the steel wire mesh framework polyethylene composite pipe; and the end of the steel wire mesh framework polyethylene composite pipe is folded towards the outer steel ring, the folded position extends to the protrusion, and an inner steel ring is embedded in the outer part of the folded steel wire mesh framework polyethylene composite pipe. The problems that in the prior art, steel wires at the end of steel wire mesh framework polyethylene composite pipes are prone to scattering, and in the connecting process, a sealing gasket and a flange are prone to leaking and falling off; and the tightening degrees of bolts on the flange need to be completely consistent, so that the operation is very difficult are solved.

A dithiocarbamate functionalized dendrimer with an alkylenediamine core, a dithiocarbamate pendant functional group and a dithiocarbamate end functional group, as a soil heavy metal immobilization amendment, and a preparation method thereof are provided. The dithiocarbamate functionalized dendrimer has a chemical formula of (CH₂)_a{N[CH₂CH₂COOCH₂C(C₂H₅)(CH₂OCOCH₂CH₂N(CSSM)CH₂(CH₂)_bCH₂N(CSS M)₂)₂]₂}₂, wherein a is a positive integer larger than 2; b is a positive integer at a range of 0-4; and M is Na⁺, NH₄⁺ or K⁺. The dithiocarbamate functionalized dendrimer with the alkylenediamine core is used for an in-suit immobilization remediation for soil contaminated by heavy metals, and has advantages of a small dosage, high efficiency, safety and rapidness. The dendrimer is able to effectively immobilize exchangeable and carbonated bound forms of the heavy metals, in such a manner that the immobilized heavy metals are able to resist an influence from natural environment for a long term, such as an acid rain.

The invention discloses an alcoholic beverage for preventing cervical spondylosis, lumbar disc herniation and scapulohumeral periarthritis, and belongs to the technical field of beverages. The formula of the alcoholic beverage comprises the following components, by weight, 2-10 parts of mulberry, 2-10 parts of wolfberry fruit, 3-10 parts of Polygonatum sibiricum, 2-10 parts of dahurian angelica root, 2-10 parts of Peach Seed, 1-5 parts of safflower, 2-10 parts of Radix Puerariae, 2-10 parts of sophora japonica, 30-60 parts of distilled water, 5-10 parts of honey, and 100-200 parts of a white wine. The alcoholic beverage is compounded according to the traditional Chinese medicinal theoretic composition, has the efficacies of liver and kidney nourishing, blood circulation invigorating, vein relaxing and pain relieving, treats alcohol as a carrier, makes nutrients reach all corners of a body as possible by means of the diffusion performance of the wine, and especially reach positions comprising cervical vertebra, lumbar vertebra and shoulder joints which cannot be reached by routine aqueous solutions, and has the advantages of taking convenience, substantial improvement of the sleep condition of a patient, and benefiting for the physical and mental health of the patient.

The invention relates to a water level amplitude area panel maintenance intelligent system and a control and maintenance method. The water level amplitude area panel maintenance intelligent system includes a drainage floral tube fixedly arranged on a concrete panel, the drainage floral tube is in communication with the bottom of a water box through a first communication tube and an electrically operated valve, and the water box is connected with a water supply device; a temperature acquisition instrument for monitoring environmental temperature is installed on the concrete panel and on the middle part of the top of the drainage floral tube; the concrete panel is mounted with an evaporation quantity detection device for monitoring the evaporation amount of water in a dam body; and the temperature acquisition instrument, the water supply device and the evaporation quantity detection device are connected with a hardware control device through a signal line and automatically control the drainage operation of the drainage floral tube. The water level amplitude area panel maintenance intelligent system aims to solve the problem that the existing built concrete panel dam is prone to beingcracked due to the large temperature difference of climate and the improper maintenance of the water level amplitude area panel during the operation period.

The invention discloses an immunogenic oligopeptide aiming at an ETAR-RhoE pathway, a vaccine of the immunogenic oligopeptide and an application of the immunogenic oligopeptide to improvement of heart remodeling, and belongs to the field of biological medicine, the oligopeptide is coupled with carrier hemocyanin KLH or tetanus toxoid through a glutaraldehyde coupling method to form hapten oligopeptide-carrier protein (complete antigen: RG10 therapeutic oligopeptide). The therapeutic oligopeptide can stimulate a body to generate a target antibody with high antibody titer and lasting titer by being supplemented with an adjuvant. The RG10 therapeutic oligopeptide can be developed as an efficient and brand-new therapeutic means for clinically improving heart remodeling, and has great future application potential.

Disclosed is a protective layer to protect a lithium metal negative electrode for a lithium secondary battery, in which the protective layer may inhibit formation of lithium dendrite and improve thermal/chemical stability, and conductivity of lithium ions. Further, disclosed are a production method of the protective layer, and a lithium secondary battery including the protectively layer. The protective layer contains a poly(arylene ether sulfone)-poly(ethylene glycol) graft copolymer represented by a following Chemical Formula 1:

The invention relates to a zipper type ground fracture repairing device and a using method. The device comprises a ground fracture; a plurality of cover plates are covered along the length direction of the ground fracture; each cover plate comprises a cuboid first cover plate and a cuboid second cover plate which are the same in size; first buckling parts are arranged at the ends, in the length direction, of the first cover plates, second buckling parts are arranged at the ends, in the length direction, of the second cover plates, the two first cover plates are matched through the first buckling parts to form a main cover plate, the first buckling parts of the first cover plates and the second buckling parts of the second cover plates are matched to form auxiliary cover plates, and the cover plates are further filled with multiple layers of materials. The cover plate can adapt to the ground fracture, so that the cover plate can better adapt to horizontal tension deformation, vertical dislocation deformation and slight twisting deformation of the ground fracture, roadbed engineering on the ground crack is ensured to be safe and stable, and engineering construction safety on the ground crack is ensured.

The invention discloses an electrochemical device and electric equipment. The electrochemical device comprises an electrode assembly, the electrode assembly comprises a first pole piece, a first isolation layer, a second pole piece and a second isolation layer, the first isolation layer is located between the first pole piece and the second pole piece, and the second pole piece is located between the first isolation layer and the second isolation layer; in the first direction, the first isolation layer comprises a first extension part exceeding the second pole piece, and the second isolation layer comprises a second extension part exceeding the second pole piece; the first extending part comprises a first bonding area, the second extending part comprises a second bonding area, the bonding force between the first bonding area and the second bonding area is F1, and F1 is larger than or equal to 5N/m. According to the electrochemical device, the isolating layers on the two sides of the pole pieces are bonded, the isolating layers are prevented from shrinking at high temperature, or the isolating layers are prevented from turning inwards at the edge due to impact of electrolyte during falling, and isolation between the positive pole piece and the negative pole piece is ensured to prevent short circuit.

The invention relates to a simulated work condition detecting method for a 50,000 ton/year methionine propylene oxidation reactor. The method comprises the steps that air is blown to an oxidizer through an air blower, air is heated to the temperature of 160-170 DEG C by an air heater, inputted hot air can gradually increase the temperature of the oxidizer to 160 DEG C to meet the requirements for adding fused salt, two sections of the oxidizer are filled up with the fused salt successively, the temperature of the oxidizing section increases from 160 DEG C to 350 DEG C, the salt temperature of the reaction section increases to 350 DEG C to be insulated for more than or equal to 24 hours, and the temperature of a quenching section gradually increases to 300 DEG C to be insulated for more than or equal to 24 hours. When the temperature of the oxidizing section and the temperature of the quenching section increase by every 50 DEG C in a temperature rise process, whether fused salt leaks out of an upper pipe plate and a lower pipe plate is checked, thermal insulation is carried out for 24 hours, fused salt leakage is not observed to prove that the equipment quality meets production and using requirements, and then the temperature is slowly cooled down. In detection, the quality defect which cannot be found in cold mold detection of a traditional detecting method is overcome and repaired in time, and a lot of economical loss caused by shutdown and repair of the quality problem is avoided.