The invention discloses a surge protection device of mid-span active Ethernet. The active Ethernet adopts mid-span, the surge protection device comprises a network signal protection unit, a power supply unit, an RJ45 input interface and an RJ45 output interface, the network signal protection unit comprises a first tripolar gas discharge tube, a second tripolar gas discharge tube, a first resistor, a second resistor, a third resistor, a fourth resistor, a firs directional transient voltage suppressor and a second directional transient voltage suppressor, and the power supply unit comprises a first piezoresistor, a second piezoresistor, a third piezoresistor, a first inductor, a second inductor and a temperature fuse. The mid-span active Ethernet can suppress lightning overvoltage formed by electrostatic induction of lightning and electromagnetic induction, lightning current energy is released, and normal operation of the active Ethernet is ensured.