The invention discloses a respiratory tract cleaning device. The device comprise a cleaning device main body and a cleaning probe main body, the right side of the cleaning device main body is connected with the cleaning probe main body through a connecting pipe, the outer wall of the cleaning probe main body is sleeved with a rectangular box, the front side of the rectangular box is inserted witha cylinder, the rear side of the cylinder is clamped with an inserting rod, the outer wall of the inserting rod is sleeved with a spring, the rear side of the inner cavity of the rectangular box is connected with a screw rod through a bearing in the left and right directions, and the outer wall of the screw rod is provided with an expansion structure. By pulling the cylinder to the front side, thespring can be stretched, the inserting rod can be separated from the inner cavity of the a clamping groove, the rectangular box can be conveniently disassembled, time and labor are saved, the deviceis convenient for sterilization treatment and for multiple uses, the mouth can be supported by a retractable structure, the mouth of a patient can be prevented from closing in the cleaning process, mouth closing results in damage to the device, the risk of medical accidents can be reduced at the same time, and a bracket can be adjusted according to patients of different ages so as to make the patients more comfortable.