26 results about "Atrial tissue" patented technology

A valve frame includes a tubular portion defining a plurality of valve-frame coupling elements disposed circumferentially around a longitudinal axis of the valve frame, and a plurality of arms, extending radially outward from an upstream portion of the tubular portion to define an arm span, and configured to engage tissue in the atrium. An outer frame is coupled to the valve frame, and includes a ring circumscribing the tubular portion, and a plurality of flanges that extend radially outward from the ring to define a flange span, and are configured to engage ventricular tissue. Each arm defines a rigid portion and a flexible portion that is disposed radially outward from the rigid portion, and is more flexible than the rigid portion. The majority of the flexible portion is disposed further radially outward than the flange span. Other embodiments are also described.

The application relates to the field of medical devices, in particular to an implant capable of avoiding interlayer reflux, which comprises an anchoring device, a closing aid, and an adjusting mechanism, the closing aid is fixed on atrial tissue through the anchoring device, one end of the adjusting mechanism is connected with the closing aid, and the other end of the adjusting mechanism is fixed on ventricular tissue or apical tissue, the closing aid comprises a first patch and a second patch, one side of the first patch close to the anchoring device is a root, and the other side of the first patch away from the anchoring device is a head, wherein the first patch is arranged above the second patch, and the first patch and the second patch cooperate to form a pocket structure with an opening direction towards the head direction; the application can effectively avoid the existence of a gap between the closing aid and the autologous valve leaflet, so that blood flowing into the gap can be prevented from being accumulated into thrombus, calcified and other adverse conditions, and the application has good clinical significance.

The invention relates to the field of medical instruments, in particular to an implant capable of avoiding interlayer regurgitation, which comprises an anchoring device, a closure assisting part and an adjusting mechanism, the closure assisting part is fixed on atrial tissue through the anchoring device, one end of the adjusting mechanism is connected with the closure assisting part, and the other end of the adjusting mechanism is connected with the closure assisting part. One end of the adjusting mechanism is fixed to ventricular tissue or cardiac apex tissue, the closure assisting piece comprises a first patch and a second patch, the side, close to the anchoring device, of the first patch is a root part, the side, away from the anchoring device, of the first patch is a head part, the first patch is arranged above the second patch, and the second patch is arranged above the head part. The first patch and the second patch are matched to form a pocket structure with an opening facing the head; the closure assisting device can effectively avoid the unfavorable conditions of thrombus accumulation, calcification and the like caused by the fact that blood flows into a gap due to the gap between the closure assisting part and the autologous valve leaflet, and has very good clinical significance.

Apparatus and methods are described for treating a subject with a diseased atrioventricular valve. A docking element is implanted within the subject's atrium such that no portion of the docking element extends through the subject's atrioventricular valve. The docking becomes anchored to tissue of the atrium at least partially via ingrowth of the tissue of the atrium. The docking element includes a ring, which is implanted at the annulus of the atrioventricular valve, and a frame having a height of at least 15 mm, which extends upwardly from the ring. A prosthetic atrioventricular valve apparatus is placed at least partially inside the docking element subsequent to the ingrowth of the tissue of the atrium having occurred, and becomes anchored to the docking element, at least partially by radially expanding against the ring. Other applications are also described.

The present application relates to the field of medical devices, and in particular to a repair device for preventing valve regurgitation, comprising a fixing unit, a closing aid and an adjusting member, wherein the fixing unit is connected to the closing aid, the fixing unit is anchored at atrial tissue or an autologous valve ring, the closing aid is provided with a first frame, one end of the adjusting member is connected to the first frame, the proximal end of the adjusting member is fixed on the apex or ventricular tissue, and when the closing aid follows the movement of the autologous valve leaflet, the adjusting member and the first frame slide relative to each other; the adjusting member and the first frame can slide relative to each other, so that the closing aid can adjust its position in real time according to the direction of blood flow impact when twisting or restoring, so as to avoid stress damage to the closing aid and affect the treatment effect of regurgitation.

The invention discloses application of 9 '''-salvianolic acid B monomethyl ester in preparation of a medicine for preventing and / or treating atrial fibrillation, and belongs to the technical field of biological medicine. Experiments prove that the 9 ''-MSB disclosed by the invention can be used for remarkably improving the blood pressure rise and the atrial inner diameter increase of a mouse after Ang II perfusion; the increase of the occurrence rate and the duration time of atrial fibrillation is inhibited; macrophage infiltration, collagen deposition and oxidative stress injury of atrial tissues are reduced, and the protective effect of 9 ''-MSB is obviously superior to that of SalB. Therefore, the 9 ''-MSB can be used for preparing the medicine for preventing and / or treating the atrial fibrillation, and the invention proves that the 9''-MSB can be used as a new medicine for adjuvant treatment of the atrial fibrillation and has important clinical guiding significance.

The application relates to the field of medical devices, in particular to a heart implant, which comprises an anti-reflux prosthesis, a fixing member and a limiting member, the anti-reflux prosthesis is anchored on atrial tissue through the fixing member, one end of the limiting member is connected with the anti-reflux prosthesis, and the other end of the limiting member is fixed on apical tissue, the anti-reflux prosthesis comprises a closing aid and a barrier, the distal end of the barrier is fixed on the middle region of the closing aid, the proximal end of the barrier is connected with the limiting member, and the proximal end part of the closing aid is free; the application not only can increase the coaptation area with adjacent native leaflets to achieve ideal repair effect, but also can avoid the closing aid from floating into the atrium, and has good clinical significance.

The invention provides a valve replacement system which is used for replacing a native atrioventricular valve and comprises a butt joint device, an anchoring device and a valve prosthesis. The docking device is configured to be positioned through the anchoring and locking device and provide an accommodating cavity; the anchoring and locking device comprises a plurality of anchoring pieces, a plurality of locking pieces and a plurality of flexible linear pieces, wherein the number of the locking pieces is the same as that of the anchoring pieces, and the number of the flexible linear pieces is the same as that of the anchoring pieces. In the deployment completion state, one end of a linear piece is correspondingly and fixedly connected with an anchoring piece, and the other end of the linear piece penetrates through the butt joint device and then is correspondingly and fixedly connected with a locking piece; at least one anchoring piece is anchored into ventricular tissue, and at least another anchoring piece is anchored into annulus tissue or atrial tissue; the linear piece is tensioned by the anchoring piece and the locking piece which are correspondingly located on the two opposite sides of the butt-joint device, so that the butt-joint device is pressed against the native valve ring to be positioned; the valve prosthesis is arranged in the containing cavity of the butt joint device in a penetrating mode and is reliably fixed by the butt joint device.

Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (AF) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. A patient-specific model of the atria may be generated from the three-dimensional imaging data. Simulation of the AF on the patient-specific model may be conducted to identify AF-perpetrating regions. One or more ablation locations in the atria may be identified from the AF-perpetrating regions.

A heart valve including a housing and a conductive mesh structure coupled to the housing. The conductive mesh structure includes a plurality of conductive tines that move between a collapsed position and a deployed position and the plurality of conductive tines electrically connect atrial tissue and ventricular tissue of a patient in the deployed position. The heart valve also includes a conduction controller positioned in the housing and electrically connected to the conductive mesh structure. The conduction controller receives a first conduction signal of the atrial tissue via the plurality of conductive tines, transmits a second conduction signal to the ventricular tissue via the plurality of conductive tines, and controls an electrical conduction pathway of the patient based on the second conduction signal.

A heart tissue model including a heart tissue with at least one inner cavity or a central chamber, wherein the heart tissue model including at least two different heart tissues selected from left ventricle tissue, right ventricle tissue, atrial tissue, outflow tract tissue, atrioventricular canal tissue, sinoatrial node tissue, and atrioventricular node tissue, wherein the central chamber can be shared by at least two different heart tissues, and wherein the at least two different heart tissues include a calcium signaling connection and / or ability to propagate a tissue contraction-; methods of generating such a tissue model and uses of the tissue model for screening purposes is disclosed.

This application belongs to the field of medical devices, specifically relating to a valve prosthesis and its delivery system for preventing paravalvular leakage. It includes a leak-proof device and a stent. The stent includes a valve suture segment. The leak-proof device is connected to the proximal portion of the stent. The leak-proof device has an irregular structure and has a first form and a second form. When the leak-proof device is in the first form, it is offset from the valve suture segment in the axial direction. When the leak-proof device changes from the first form to the second form, it returns to the preset form along a preset path towards the distal end of the stent, and at least a portion of the leak-proof device overlaps with the valve suture segment in the axial direction. This invention achieves a significant reduction in tube diameter and can specifically adapt to the physiological structure of the autologous valve, allowing it to better fit the autologous valve annulus and atrial tissue, effectively preventing regurgitation.

The application relates to the field of medical devices, in particular to a repair device capable of avoiding interlayer reflux, which comprises a closing aid, an anchoring device for fixing the closing aid on atrial tissue, the closing aid comprises a first patch and a second patch, one side of the first patch close to the anchoring device is a root, one side of the first patch away from the anchoring device is a head, the first patch is arranged above the second patch, the first patch and the second patch cooperate to form a pocket structure with an opening direction towards the head direction, and the pocket structure is in a distraction state in a natural state. The application can effectively avoid the existence of a gap between the closing aid and the autologous leaflet, so that blood flowing into the gap can be prevented from being accumulated into thrombus, calcified and other adverse conditions, and has good clinical significance.

The present invention provides: a cardiac tissue model comprising cardiac tissue having at least one internal cavity or chamber wherein the cardiac tissue model comprises at least two different cardiac tissues selected from the group consisting of left ventricular tissue, right ventricular tissue, atrial tissue, outflow tract tissue, atrioventricular tube tissue, sinus node tissue and atrioventricular node tissue, wherein the central chamber may be common to at least two different cardiac tissues, and wherein the at least two different cardiac tissues comprise the ability to connect calcium signaling and / or propagate tissue contraction; methods of generating such tissue models, and uses of tissue models for screening purposes.

The invention relates to the field of medical instruments, in particular to a repair instrument capable of avoiding interlayer reflux, which comprises a closure assisting part and an anchoring device used for fixing the closure assisting part on atrial tissue, the closure assisting part comprises a first patch and a second patch, one side, close to the anchoring device, of the first patch is a root part, and the other side, close to the anchoring device, of the second patch is a root part; the side, away from the anchoring device, of the first patch is a head, the first patch is arranged above the second patch, the first patch and the second patch are matched to form a pocket structure with an opening facing the head, and in the natural state, the pocket structure is in an open state. The closure assisting device can effectively avoid the unfavorable conditions of thrombus accumulation, calcification and the like caused by the fact that blood flows into a gap due to the gap between the closure assisting part and the autologous valve leaflet, and has very good clinical significance.

The invention discloses a method for aseptically separating myocardial cells from the heart of an adult mouse. The method comprises the following steps: (1) transferring the heart into a super clean bench; (2) connecting a flow guide tube at the ascending aorta, and ligating and fixing; (3) injecting an EDTA (Ethylene Diamine Tetraacetic Acid) buffer solution from the flow guide tube, wherein the injection rate is 1.5-2.5 ml / min; (4) injecting a perfusion buffer solution from the flow guide tube at the same injection rate; (5) injecting a digestive enzyme buffer solution from the diversion tube, wherein the injection rate is 1.0-1.5 ml / min; (6) repeating the step (5) until the heart is completely digested; (7) removing aorta and atrium tissues, gently shredding the remaining part, continuing to add the digestive enzyme buffer solution, and gently blowing and beating until the ventricular tissues are dissociated into single cells; (8) adding a digestion stop solution, and gently blowing and beating; and filtering and centrifuging the cell suspension to obtain the myocardial cells. The separation process does not depend on a langendorff perfusion system.

The present application relates to the field of medical devices, and in particular to an artificial leaflet device for improving the engagement of a heart valve, comprising a fixed frame, a coapting leaflet, a fixed needle, and a limiting wire, wherein the fixed frame is coated with a fabric layer, the fixed frame is anchored to an autologous valve ring or atrial tissue through the fixed needle, one end of the limiting wire is connected to the coapting leaflet, and the other end of the limiting wire is fixed to chordae tendineae or papillary muscles, and a fitting device is arranged on the fixed frame, the fitting device comprises a threaded needle and a lower pressing plate, wherein the lower pressing plate is located in the middle area of ​​the coapting leaflet, when implanted, the threaded needle passes through the fabric layer on the fixed frame and penetrates into the atrial tissue, the lower pressing plate is closely attached to the middle area of ​​the coapting leaflet and makes the middle area of ​​the coapting leaflet closely attached to the atrial tissue or the autologous valve leaflet; the present invention can effectively avoid gaps between the closing aid and the autologous valve leaflet, avoid blood leakage from both sides of the coapting leaflet, thereby effectively avoiding blood reflux, and has good clinical significance.

The invention discloses application of 6RK73 in preparation of a medicine for preventing or treating atrial fibrillation and a medicine composition for preventing or treating atrial fibrillation. According to the application disclosed by the invention, by injecting the 6RK73 into the intraperitoneal cavity of an atrial fibrillation (especially Ang II induced) mouse for pretreatment, the 6RK73 is found to be capable of obviously reducing the atrial fibrillation area, improving inflammatory response and oxidative stress in atrial tissues and relieving atrial structure remodeling so as to prevent and treat atrial fibrillation, and a new medicine and a new treatment scheme are provided for clinical treatment of atrial fibrillation patients.

The present application relates to the field of medical devices, and in particular to an implantable device for treating valvular regurgitation, comprising a fixing bracket, a closing aid, a fixing member and an adjustment mechanism, wherein the closing aid is anchored to atrial tissue through the fixing member, one end of the adjustment mechanism is connected to the closing aid, and one end of the adjustment mechanism is fixed to ventricular tissue or apical tissue, the closing aid comprises an upper region and a lower region, the fixing bracket is connected to the upper region, and one end of the adjustment mechanism is connected to the lower region, wherein both sides of the upper region are concave toward the center of the upper region, and a shape retaining member is provided at the junction of the upper region and the lower region; the present invention can effectively avoid interference between the closing aid and the native anterior valve leaflet, resulting in wrinkles, thrombus accumulation, calcification and other adverse conditions of the closing aid, and has great clinical significance.

The present disclosure provides ex vivo chamber-specific cardiac tissues, methods for generating the cardiac tissues in a bioreactor, and methods of using the cardiac tissues. Examples of cardiac tissues that can be generated include, but are not limited to, atrial tissues, ventricular tissues, and composite tissues having an atrial tissue connected to a ventricular tissue.

This application belongs to the field of medical devices, and specifically relates to a repair device for preventing valve regurgitation, including an installation stent, a single anti-regurgitation leaflet prosthesis, and a fixing member; the proximal end of the installation stent abuts against the autologous valve annulus or atrial tissue, and the distal end of the installation stent is fixed to the ventricular tissue through the fixing member; wherein, the single anti-regurgitation leaflet prosthesis is connected to the installation stent, and when the autologous valve is in the closed state, the single anti-regurgitation leaflet prosthesis is located in the middle of the autologous valve; in an embodiment of the present invention, the repair device is fixed to the ventricular tissue through the fixing member, only replaces the problematic leaflets, thereby retaining the original functions of the remaining part of the autologous leaflets, and at the same time does not change the shape of the autologous valve annulus, causing little damage to the intracardiac tissue, and at the same time, the implantation amount of the implant is less and the irritation is small.

The invention relates to a shunt stoma system, and belongs to the technical field of medical instruments. According to the atrial tissue cutting device, the pushing tube movably penetrates through the shunting sheath tube, the connecting rod movably penetrates through the pushing tube, the plug is connected with the connecting rod, and the cutter is arranged at the far end of the pushing tube, so that the plug and the cutter can be conveniently matched to clamp the atrial tissue to be cut, and the pushing tube can conveniently drive the cutter to rotate and move so as to cut the clamped tissue; according to the split-flow ostomy device, the cutter is arranged at the far end of the cutter, and the plug plugs the far end opening of the cutter, so that the cut tissue is plugged in a space formed by the plug and the cutter, the cut tissue can be conveniently withdrawn out of a body along with the split-flow ostomy device, and the cut tissue is prevented from being left in the atrium; the shunt stoma device in the system is reasonable in structural design and convenient to use, and cut tissue cannot fall off easily in the withdrawing process.

The invention relates to the field of medical instruments, in particular to an implantation instrument for treating valve regurgitation, which comprises a fixing support, a closure assisting part, a fixing part and an adjusting mechanism, the closure assisting part is anchored on atrial tissue through the fixing part, one end of the adjusting mechanism is connected with the closure assisting part, one end of the adjusting mechanism is fixed on ventricular tissue or cardiac apex tissue, and the other end of the adjusting mechanism is connected with the fixing part. The closing assisting part comprises an upper area and a lower area, the fixing support is connected with the upper area, one end of the adjusting mechanism is connected with the lower area, the two sides of the upper area are inwards concave towards the center of the upper area, and a shape maintaining part is arranged at the junction of the upper area and the lower area; according to the invention, unfavorable conditions of wrinkling, thrombus accumulation, calcification and the like of the closure assisting part caused by mutual interference between the closure assisting part and the autologous anterior valve leaflet can be effectively avoided, and good clinical significance is achieved.

The present application relates to the field of medical devices, and in particular to a repair system for improving the engagement of heart valves, comprising an outer sheath, an artificial valve leaflet, an anchoring needle, and an adjusting device, wherein the adjusting device comprises a first tube, a first guide wire, a second tube, a second guide wire, an abutment member, a threaded needle, a fitting member, and an operating rod, wherein the first tube is detachably connected to the artificial valve leaflet via the first guide wire, the fitting member is arranged between the first tube and the second tube, and when the operating rod is rotated to allow the threaded needle to pass through the artificial valve leaflet and penetrate into the heart tissue, the fitting member is located in the middle region of the artificial valve leaflet close to the native valve ring, so that the middle region is in close contact with the atrial tissue or the native valve leaflet; the present invention can effectively avoid the presence of a gap between the closing aid and the native valve leaflet, so that blood flows into the gap and causes adverse conditions such as thrombus accumulation and calcification, and has great clinical significance.

The application relates to the field of medical devices, in particular to an implant device for valvuloplasty, which comprises a ring shrinkage component, a control element for controlling the shrinkage of the ring shrinkage component, a fixing element for anchoring the ring shrinkage component to heart tissue, the ring shrinkage component comprises a first ring shrinkage component and a second ring shrinkage component, the ring shrinkage component is anchored adjacently to a set ring shrinkage area of an autologous valve ring or atrium tissue through the fixing element, further comprising an elastic component, the elastic component is connected with the ring shrinkage component, the elastic component is provided with a channel, the control element is connected with the elastic component through the channel, and the control element is operated to drive the elastic component to shrink, the elastic component further drives the ring shrinkage component to uniformly shrink; the application not only simplifies the structure of the implant device, but also can realize uniform shrinkage, reduce the damage to the heart tissue, and has good clinical significance.

Medical apparatus and methods for diagnostic and site determination of cardiac arrhythmias within a heart of a subject are provided. A computing device receives, records and processes electrocardiogram (ECG) signals in the form of bipolar and unipolar ECGs associated with respective cardiac tissue locations corresponding to catheter distal end sensors on locations. Unipolar ECGs that include signals from a plurality of successive heartbeats corresponding to locations within an area of study are analyzed to identify Fractionated Unipolar ECG Signal Complexes (FUESCs) of unipolar ECGs by defining complexes of the unipolar ECGs that correspond to respective bipolar activity windows. Identified arrhythmia sites for treatment include a predetermined number of unipolar ECGs that have a predetermined number of FUESCs. Atrial arrhythmia sites for treatment by ablation can be identified with respect to FUESCs of unipolar ECGs that include signals from at least ten successive heartbeats of an atrial tissue study area.