11 results about "Atrial tissue" patented technology

A valve frame includes a tubular portion defining a plurality of valve-frame coupling elements disposed circumferentially around a longitudinal axis of the valve frame, and a plurality of arms, extending radially outward from an upstream portion of the tubular portion to define an arm span, and configured to engage tissue in the atrium. An outer frame is coupled to the valve frame, and includes a ring circumscribing the tubular portion, and a plurality of flanges that extend radially outward from the ring to define a flange span, and are configured to engage ventricular tissue. Each arm defines a rigid portion and a flexible portion that is disposed radially outward from the rigid portion, and is more flexible than the rigid portion. The majority of the flexible portion is disposed further radially outward than the flange span. Other embodiments are also described.

The application relates to the field of medical devices, in particular to an implant capable of avoiding interlayer reflux, which comprises an anchoring device, a closing aid, and an adjusting mechanism, the closing aid is fixed on atrial tissue through the anchoring device, one end of the adjusting mechanism is connected with the closing aid, and the other end of the adjusting mechanism is fixed on ventricular tissue or apical tissue, the closing aid comprises a first patch and a second patch, one side of the first patch close to the anchoring device is a root, and the other side of the first patch away from the anchoring device is a head, wherein the first patch is arranged above the second patch, and the first patch and the second patch cooperate to form a pocket structure with an opening direction towards the head direction; the application can effectively avoid the existence of a gap between the closing aid and the autologous valve leaflet, so that blood flowing into the gap can be prevented from being accumulated into thrombus, calcified and other adverse conditions, and the application has good clinical significance.

The invention discloses application of 9 '''-salvianolic acid B monomethyl ester in preparation of a medicine for preventing and / or treating atrial fibrillation, and belongs to the technical field of biological medicine. Experiments prove that the 9 ''-MSB disclosed by the invention can be used for remarkably improving the blood pressure rise and the atrial inner diameter increase of a mouse after Ang II perfusion; the increase of the occurrence rate and the duration time of atrial fibrillation is inhibited; macrophage infiltration, collagen deposition and oxidative stress injury of atrial tissues are reduced, and the protective effect of 9 ''-MSB is obviously superior to that of SalB. Therefore, the 9 ''-MSB can be used for preparing the medicine for preventing and / or treating the atrial fibrillation, and the invention proves that the 9''-MSB can be used as a new medicine for adjuvant treatment of the atrial fibrillation and has important clinical guiding significance.

The application relates to the field of medical devices, in particular to a heart implant, which comprises an anti-reflux prosthesis, a fixing member and a limiting member, the anti-reflux prosthesis is anchored on atrial tissue through the fixing member, one end of the limiting member is connected with the anti-reflux prosthesis, and the other end of the limiting member is fixed on apical tissue, the anti-reflux prosthesis comprises a closing aid and a barrier, the distal end of the barrier is fixed on the middle region of the closing aid, the proximal end of the barrier is connected with the limiting member, and the proximal end part of the closing aid is free; the application not only can increase the coaptation area with adjacent native leaflets to achieve ideal repair effect, but also can avoid the closing aid from floating into the atrium, and has good clinical significance.

The invention provides a valve replacement system which is used for replacing a native atrioventricular valve and comprises a butt joint device, an anchoring device and a valve prosthesis. The docking device is configured to be positioned through the anchoring and locking device and provide an accommodating cavity; the anchoring and locking device comprises a plurality of anchoring pieces, a plurality of locking pieces and a plurality of flexible linear pieces, wherein the number of the locking pieces is the same as that of the anchoring pieces, and the number of the flexible linear pieces is the same as that of the anchoring pieces. In the deployment completion state, one end of a linear piece is correspondingly and fixedly connected with an anchoring piece, and the other end of the linear piece penetrates through the butt joint device and then is correspondingly and fixedly connected with a locking piece; at least one anchoring piece is anchored into ventricular tissue, and at least another anchoring piece is anchored into annulus tissue or atrial tissue; the linear piece is tensioned by the anchoring piece and the locking piece which are correspondingly located on the two opposite sides of the butt-joint device, so that the butt-joint device is pressed against the native valve ring to be positioned; the valve prosthesis is arranged in the containing cavity of the butt joint device in a penetrating mode and is reliably fixed by the butt joint device.

A heart tissue model including a heart tissue with at least one inner cavity or a central chamber, wherein the heart tissue model including at least two different heart tissues selected from left ventricle tissue, right ventricle tissue, atrial tissue, outflow tract tissue, atrioventricular canal tissue, sinoatrial node tissue, and atrioventricular node tissue, wherein the central chamber can be shared by at least two different heart tissues, and wherein the at least two different heart tissues include a calcium signaling connection and / or ability to propagate a tissue contraction-; methods of generating such a tissue model and uses of the tissue model for screening purposes is disclosed.

This application belongs to the field of medical devices, specifically relating to a valve prosthesis and its delivery system for preventing paravalvular leakage. It includes a leak-proof device and a stent. The stent includes a valve suture segment. The leak-proof device is connected to the proximal portion of the stent. The leak-proof device has an irregular structure and has a first form and a second form. When the leak-proof device is in the first form, it is offset from the valve suture segment in the axial direction. When the leak-proof device changes from the first form to the second form, it returns to the preset form along a preset path towards the distal end of the stent, and at least a portion of the leak-proof device overlaps with the valve suture segment in the axial direction. This invention achieves a significant reduction in tube diameter and can specifically adapt to the physiological structure of the autologous valve, allowing it to better fit the autologous valve annulus and atrial tissue, effectively preventing regurgitation.

The application relates to the field of medical devices, in particular to a repair device capable of avoiding interlayer reflux, which comprises a closing aid, an anchoring device for fixing the closing aid on atrial tissue, the closing aid comprises a first patch and a second patch, one side of the first patch close to the anchoring device is a root, one side of the first patch away from the anchoring device is a head, the first patch is arranged above the second patch, the first patch and the second patch cooperate to form a pocket structure with an opening direction towards the head direction, and the pocket structure is in a distraction state in a natural state. The application can effectively avoid the existence of a gap between the closing aid and the autologous leaflet, so that blood flowing into the gap can be prevented from being accumulated into thrombus, calcified and other adverse conditions, and has good clinical significance.

The present application relates to the field of medical devices, and in particular to an implantable device for treating valvular regurgitation, comprising a fixing bracket, a closing aid, a fixing member and an adjustment mechanism, wherein the closing aid is anchored to atrial tissue through the fixing member, one end of the adjustment mechanism is connected to the closing aid, and one end of the adjustment mechanism is fixed to ventricular tissue or apical tissue, the closing aid comprises an upper region and a lower region, the fixing bracket is connected to the upper region, and one end of the adjustment mechanism is connected to the lower region, wherein both sides of the upper region are concave toward the center of the upper region, and a shape retaining member is provided at the junction of the upper region and the lower region; the present invention can effectively avoid interference between the closing aid and the native anterior valve leaflet, resulting in wrinkles, thrombus accumulation, calcification and other adverse conditions of the closing aid, and has great clinical significance.

The invention relates to a shunt stoma system, and belongs to the technical field of medical instruments. According to the atrial tissue cutting device, the pushing tube movably penetrates through the shunting sheath tube, the connecting rod movably penetrates through the pushing tube, the plug is connected with the connecting rod, and the cutter is arranged at the far end of the pushing tube, so that the plug and the cutter can be conveniently matched to clamp the atrial tissue to be cut, and the pushing tube can conveniently drive the cutter to rotate and move so as to cut the clamped tissue; according to the split-flow ostomy device, the cutter is arranged at the far end of the cutter, and the plug plugs the far end opening of the cutter, so that the cut tissue is plugged in a space formed by the plug and the cutter, the cut tissue can be conveniently withdrawn out of a body along with the split-flow ostomy device, and the cut tissue is prevented from being left in the atrium; the shunt stoma device in the system is reasonable in structural design and convenient to use, and cut tissue cannot fall off easily in the withdrawing process.

Medical apparatus and methods for diagnostic and site determination of cardiac arrhythmias within a heart of a subject are provided. A computing device receives, records and processes electrocardiogram (ECG) signals in the form of bipolar and unipolar ECGs associated with respective cardiac tissue locations corresponding to catheter distal end sensors on locations. Unipolar ECGs that include signals from a plurality of successive heartbeats corresponding to locations within an area of study are analyzed to identify Fractionated Unipolar ECG Signal Complexes (FUESCs) of unipolar ECGs by defining complexes of the unipolar ECGs that correspond to respective bipolar activity windows. Identified arrhythmia sites for treatment include a predetermined number of unipolar ECGs that have a predetermined number of FUESCs. Atrial arrhythmia sites for treatment by ablation can be identified with respect to FUESCs of unipolar ECGs that include signals from at least ten successive heartbeats of an atrial tissue study area.